Anti-Mouse CD103 Antibody (AF 488) [M290](AGEL0333)

Mouse CD103 Monoclonal Antibody (Alexa Fluor 488 Conjugated) [M290](AGEL0333)

SKU AGEL0333

Product Type Antibody

Antibody Type Monoclonal Antibody

Reactivity Mouse

Host Species Rat

Isotype IgG2a

Clone M290

Conjugation AF 488

Applications FC

Description

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Antibody Name:	Mouse CD103 Monoclonal Antibody (Alexa Fluor 488 Conjugated)
Antibody Code:	AGEL0333
Size:	50 Tests
Clone:	M290
Synonyms:	Integrin alpha-E, Itgae, Integrin alpha M290, CD103
Host Species:	Rat
Species Reactivity:	Mouse
Applications:	FC

Concentration:	5uL
Isotype:	IgG2a
Conjugation:	Alexa Fluor 488
Applications:	FC
Recommended Dilution:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. The amount of the reagent is suggested to be used 5 uL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Storage Buffer:	PBS with 0.05% Proclin300, 1% BSA
Storage:	Keep as concentrated solution.Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.

Gene ID:	16407
Uniprot:	Q60677
Background:	CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.