Mouse Caspase-8/CASP8 Recombinant Protein (His tag)
- SKU:
- RPES5744
- Product Type:
- Recombinant Protein
- Species:
- Mouse
Description
| Product Name: | Mouse Caspase-8/CASP8 Recombinant Protein (His tag) |
| Product Code: | RPES5744 |
| Size: | 20µg |
| Species: | Mouse |
| Expression Host: | E.coli |
| Synonyms: | CASP8_MOUSE, Caspase-8, Casp8, EC:3.4.22.61 |
| Mol Mass: | 17.27 kDa |
| AP Mol Mass: | 20 kDa |
| Tag: | N-His |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | Please contact us for more information. |
| Bio Activity: | Testing in progress |
| Sequence: | Ser 219-Gly 376 |
| Accession: | O89110 |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation: | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution: | Please refer to the printed manual for detailed information. |
| Background: | Caspase-8 (Cysteine-aspartic acid protease 8/Casp8a; also named MCH5, FLICA and MACH alpha 1) is a 28 kDa member of the peptidase C14A family of enzymes. It is widely expressed and is considered an initiating caspase for the apoptotic cascade. Caspase-8 acts on a wide variety of substrates, including procaspases‑3, 4, 6, 7, 9 and 10, c‑FLIPL and procaspase-8 itself. Human procaspase‑8a is a 54‑56 kDa, 479 amino acid (aa) protein. It contains two N‑terminal death domains (aa 1‑177), followed by a catalytic site that utilizes His317Gly318 plus Cys360. Normally, it is an inactive, cytosolic monomer. But following death‑domain (DD) containing receptor oligomerization, Caspase‑8 is recruited to the death-inducing signaling complex (DISC) that forms around the death domains of the oligomerized receptor. |
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