Chemokines Recombinant Proteins

Mouse BRAK Recombinant Protein (RPPB1104)

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SKU:
RPPB1104
Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
Q9WUQ5
Research Area:
Chemokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Mouse BRAK Recombinant Protein
Product Code:RPPB1104
Size:20µg
Species:Mouse
Target:BRAK
Synonyms:C-X-C motif chemokine 14, B-cell and monocyte-activating chemokine, Chemokine BRAK, Kidney-expressed chemokine CXC, MIP-2G, Small-inducible cytokine B14, Cxcl14, Bmac, Kec, Ks1, Mip2g, Scyb14, BRAK, NJAC, AI414372, bolekine, MIP2gamma, 1110031L23Rik, 1200006I23Rik.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:CXCL14 was lyophilized from a 0.2�m filtered concentrated solution in 20mM PB, pH 7.4 and 500mM NaCl.
Solubility:It is recommended to reconstitute the lyophilized CXCL14 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized CXCL14 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL14 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.
Purity:Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:SKCKCSRKGP KIRYSDVKKL EMKPKYPHCE EKMVIVTTKS MSRYRGQEHC LHPKLQSTKR FIKWYNAWNE KRRVYEE
Biological Activity:The ED50 of CXCL14 as determined by its ability to chemoattract activated monocytes using a concentration range of 1.0-10.0 ng/ml.

CXCL14 is involved in immunoregulatory and inflammatory processes. BRAK protein is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. CXCL14 displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. CXCL14 is involved in the homeostasis of monocyte-derived macrophages.

CXCL14 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 77 amino acids and having a molecular mass of 9.4kDa.The CXCL14 is purified by proprietary chromatographic techniques.

UniProt Protein Function:CXCL14: Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays. Belongs to the intercrine alpha (chemokine CxC) family.
UniProt Protein Details:

Protein type:Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 13|13 B1

Cellular Component: extracellular region; extracellular space; Golgi apparatus

Molecular Function:chemokine activity; cytokine activity

Biological Process: cell-cell signaling; immune response; inner ear development; negative regulation of myoblast differentiation

UniProt Code:Q9WUQ5
NCBI GenInfo Identifier:119392098
NCBI Gene ID:57266
NCBI Accession:NP_062514.2
UniProt Secondary Accession:Q9WUQ5,Q548T5, Q91V02, Q9JHH7,
UniProt Related Accession:Q9WUQ5
Molecular Weight:11,716 Da
NCBI Full Name:C-X-C motif chemokine 14
NCBI Synonym Full Names:chemokine (C-X-C motif) ligand 14
NCBI Official Symbol:Cxcl14��
NCBI Official Synonym Symbols:KS1; Kec; BMAC; BRAK; NJAC; MIP-2g; Scyb14; AI414372; bolekine; MIP2gamma; 1110031L23Rik; 1200006I23Rik��
NCBI Protein Information:C-X-C motif chemokine 14
UniProt Protein Name:C-X-C motif chemokine 14
UniProt Synonym Protein Names:B-cell and monocyte-activating chemokine; Chemokine BRAK; Kidney-expressed chemokine CXC; MIP-2G; Small-inducible cytokine B14
UniProt Gene Name:Cxcl14��
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