Neurotrophins Recombinant Proteins
Mouse Beta NGF Recombinant Protein (RPPB0111)
- SKU:
- RPPB0111
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P01139
- Research Area:
- Neurotrophins
Description
| Product Name: | Mouse Beta NGF Recombinant Protein |
| Product Code: | RPPB0111 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | Beta NGF |
| Synonyms: | Beta Polypeptide, NGF, NGFB, HSAN5, Beta-NGF, MGC161426, MGC161428. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The Recombinant Mouse b-NGF was lyophilized without additives. |
| Solubility: | It is recommended to reconstitute the lyophilized Murine NGF-beta in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Mouse Beta-NGF although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Murine NGF-Beta should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE . |
| Amino Acid Sequence: | MSSTHPVFHM GEFSVCDSVS VWVGDKTTAT DIKGKEVTVL AEVNINNSVF RQYFFETKCR ASNPVESGCR GIDSKHWNSY CTTTHTFVKA LTTDEKQAAW RFIRIDTACV CVLSRKATRR G |
| Biological Activity: | The Mouse b-NGF activity was measured in a cell proliferation assay using a factor-dependent human erythroleukemic cell line, TF-1, the ED50 for this effect is 0.2 ng/ml, corresponding to a Specific Activity of 5,000,000 units/mg. |
NGF-beta has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. Nerve Growth Factor was the 1st protein found from the family of neurotrophic factors that influence the growth and differentiation of sympathetic and sensory neurons. NGF consists of 3 different subunits: alpha, beta, and gamma. The beta subunit is accountable for its growth stimulating activity. The synthesis of NGF in astrocytes is enhanced by a range of cytokines such as IL1, TNF-a, PDGF & TGF-b.
Recombinant Mouse b-NGF produced in E.Coli is a noncovalently disulfide-linked homodimer, non-glycosylated, polypeptide chain containing 2 identical chains of 120 amino acids each and having a molecular mass of 13,471 Dalton each.The Recombinant Mouse-beta-NGF is purified by advanced biology purification technology.
| UniProt Protein Function: | NGF: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Homodimer. Belongs to the NGF-beta family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Cellular Component: extracellular space; cytoplasmic membrane-bound vesicle; extracellular region Molecular Function:metalloendopeptidase inhibitor activity; nerve growth factor receptor binding; growth factor activity; receptor signaling protein activity; receptor binding Biological Process: positive regulation of neuron maturation; regulation of neuron differentiation; adult locomotory behavior; positive regulation of axon extension; regulation of neurotransmitter secretion; sensory perception of pain; positive regulation of cell growth; positive regulation of protein amino acid autophosphorylation; positive regulation of nerve growth factor receptor signaling pathway; memory; regulation of release of sequestered calcium ion into cytosol; peripheral nervous system development; neuron apoptosis; induction of apoptosis via death domain receptors; positive regulation of cell proliferation; positive regulation of transcription factor activity; negative regulation of neuron apoptosis; positive regulation of neuron differentiation; positive regulation of collateral sprouting; transmembrane receptor protein tyrosine kinase signaling pathway; neurite morphogenesis; neurite development |
| UniProt Code: | P01139 |
| NCBI GenInfo Identifier: | 128162 |
| NCBI Gene ID: | 18049 |
| NCBI Accession: | P01139.2 |
| UniProt Secondary Accession: | P01139,Q63864, Q6LDB7, |
| UniProt Related Accession: | P01139 |
| Molecular Weight: | 27,077 Da |
| NCBI Full Name: | Beta-nerve growth factor |
| NCBI Synonym Full Names: | nerve growth factor |
| NCBI Official Symbol: | Ngf�� |
| NCBI Official Synonym Symbols: | Ngfb�� |
| NCBI Protein Information: | beta-nerve growth factor; beta-NGF; nerve growth factor, beta |
| UniProt Protein Name: | Beta-nerve growth factor |
| Protein Family: | Nerve growth factor |
| UniProt Gene Name: | Ngf�� |
| UniProt Entry Name: | NGF_MOUSE |
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