Mouse beta-NGF/NGFB Recombinant Protein (RPES3849)
- SKU:
- RPES3849
- Product Type:
- Recombinant Protein
- Species:
- Mouse
Description
Mouse beta-NGF/NGFB Recombinant Protein
NGF is the first member discovered in the Neurotrophin family, which includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Mouse beta -NGF is a homodimer of two 120 amino acid polypeptides. It shares approximately 90% homology at the amino acid level with human beta -NGF and 95.8% with rat beta -NGF. NGF signaling has been shown to play an important role in neuroprotection and repair. β-NGF acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival. It is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems.
| Product Name: | Mouse beta-NGF/NGFB Recombinant Protein (RPES3849) |
| Product Code: | RPES3849 |
| Size: | 10µg |
| Species: | Mouse |
| Expressed Host: | E.coli |
| Synonyms: | Beta-Nerve Growth Factor, Beta-NGF, NGF, NGFB |
| Accession: | P01139 |
| Sequence: | Met130-Arg239 |
| Activity: | Measured in a cell proliferation assay using TF?1 human erythroleukemic cells. The ED50 for this effect is 0.5-1.5 ng/ml. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Mouse beta-Nerve Growth Factor is produced by our E.coli expression system and the target gene encoding Met130-Arg239 is expressed. |
| Purity: | > 95 % as determined by SDS-PAGE |
| Mol Mass: | 12.4 kDa |
| AP Mol Mass: | 12 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 20mM Tris,200mM NaCl,pH8.0. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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