Cytokines Recombinant Proteins
Mouse BD 1 Recombinant Protein (RPPB0069)
- SKU:
- RPPB0069
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P56386
- Research Area:
- Cytokines
Description
| Product Name: | Mouse BD 1 Recombinant Protein |
| Product Code: | RPPB0069 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | BD 1 |
| Synonyms: | Beta-defensin 1, BD-1, Defensin beta 1, hBD-1, HBD1, HBP1, DEFB1, HBD-1, HBP-1, DEFB101, DEFB-1, MGC51822. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2�m filtered concentrated solution in PBS, pH7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized Mouse BD-1 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Mouse BD 1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BD 1 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | DQYKCLQHGG FCLRSSCPSN TKLQGTCKPD KPNCCKS |
| Biological Activity: | Measured by its ability to chemoattract CD34+ dendritic cells using a concentration range of 0.1-1.0 ug/ml, corresponding to a specific activity of 1,000-10,000units/mg. |
The Defensin family are highly similar in their protein sequence and are microbicidal & cytotoxic peptides made by neutrophils. Beta Defensin-1 is an antimicrobial peptide having the resistance of epithelial surfaces to microbial colonization. Beta Defensin-1 has close proximity to Defensin Alpha-1 and has been implicated in the pathogenesis of cystic fibrosis.Skin of patients having atopic dermatitis patients and mycosis fungoides (non-lesional and lesional) show lower human Beta Defensin-1 mRNA expression and higher human Beta Defensin-2 and human Beta Defensin-3 mRNA expression. Beta Defensin is highly expressed by epithelial cells. Beta-defensin 1 may play a role in the pathogenesis of severe sepsis.
BD 1 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 37 amino acids and having a molecular mass of 4.1 KDa.The BD 1 Mouse is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Function: Has bactericidal activity |
| UniProt Code: | P56386 |
| NCBI GenInfo Identifier: | 6681161 |
| NCBI Gene ID: | 13214 |
| NCBI Accession: | NP_031869.1 |
| UniProt Related Accession: | P56386 |
| Molecular Weight: | 7,749 Da |
| NCBI Full Name: | beta-defensin 1 |
| NCBI Synonym Full Names: | defensin beta 1 |
| NCBI Official Symbol: | Defb1�� |
| NCBI Official Synonym Symbols: | BD-1; AW260221�� |
| NCBI Protein Information: | beta-defensin 1 |
| UniProt Protein Name: | Beta-defensin 1 |
| UniProt Synonym Protein Names: | Defensin, beta 1 |
| Protein Family: | Beta-defensin |
| UniProt Gene Name: | Defb1�� |
| UniProt Entry Name: | DEFB1_MOUSE |
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