Cytokines Recombinant Proteins

Mouse BD 1 Recombinant Protein (RPPB0069)

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RPPB0069

Description

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Product Name:Mouse BD 1 Recombinant Protein
Product Code:RPPB0069
Size:20µg
Species:Mouse
Target:BD 1
Synonyms:Beta-defensin 1, BD-1, Defensin beta 1, hBD-1, HBD1, HBP1, DEFB1, HBD-1, HBP-1, DEFB101, DEFB-1, MGC51822.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from a 0.2�m filtered concentrated solution in PBS, pH7.4.
Solubility:It is recommended to reconstitute the lyophilized Mouse BD-1 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Mouse BD 1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BD 1 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:DQYKCLQHGG FCLRSSCPSN TKLQGTCKPD KPNCCKS
Biological Activity:Measured by its ability to chemoattract CD34+ dendritic cells using a concentration range of 0.1-1.0 ug/ml, corresponding to a specific activity of 1,000-10,000units/mg.

The Defensin family are highly similar in their protein sequence and are microbicidal & cytotoxic peptides made by neutrophils. Beta Defensin-1 is an antimicrobial peptide having the resistance of epithelial surfaces to microbial colonization. Beta Defensin-1 has close proximity to Defensin Alpha-1 and has been implicated in the pathogenesis of cystic fibrosis.Skin of patients having atopic dermatitis patients and mycosis fungoides (non-lesional and lesional) show lower human Beta Defensin-1 mRNA expression and higher human Beta Defensin-2 and human Beta Defensin-3 mRNA expression. Beta Defensin is highly expressed by epithelial cells. Beta-defensin 1 may play a role in the pathogenesis of severe sepsis.

BD 1 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 37 amino acids and having a molecular mass of 4.1 KDa.The BD 1 Mouse is purified by proprietary chromatographic techniques.

UniProt Protein Function:Function: Has bactericidal activity
UniProt Code:P56386
NCBI GenInfo Identifier:6681161
NCBI Gene ID:13214
NCBI Accession:NP_031869.1
UniProt Related Accession:P56386
Molecular Weight:7,749 Da
NCBI Full Name:beta-defensin 1
NCBI Synonym Full Names:defensin beta 1
NCBI Official Symbol:Defb1��
NCBI Official Synonym Symbols:BD-1; AW260221��
NCBI Protein Information:beta-defensin 1
UniProt Protein Name:Beta-defensin 1
UniProt Synonym Protein Names:Defensin, beta 1
Protein Family:Beta-defensin
UniProt Gene Name:Defb1��
UniProt Entry Name:DEFB1_MOUSE
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Additional Information

Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
P56386
Research Area:
Cytokines
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