Cytokines Recombinant Proteins
Mouse APRIL Recombinant Protein (RPPB0065)
- SKU:
- RPPB0065
Description
| Product Name: | Mouse APRIL Recombinant Protein |
| Product Code: | RPPB0065 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | APRIL |
| Synonyms: | Tumor necrosis factor ligand superfamily member 13, A proliferation-inducing ligand, APRIL, CD256, Tnfsf13, April. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2�m filtered concentrated solution in PBS, pH 7.4, with 0.02 % Tween-20. |
| Solubility: | It is recommended to reconstitute the lyophilized APRIL in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized APRIL although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution APRIL should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by Analysis by SDS-PAGE. |
| Amino Acid Sequence: | AVLTQKHKKK HSVLHLVPVN ITSKADSDVT EVMWQPVLRR GRGLEAQGDI VRVWDTGIYL LYSQVLFHDV TFTMGQVVSR EGQGRRETLF RCIRSMPSDP DRAYNSCYSA GVFHLHQGDI ITVKIPRANA KLSLSPHGTF LGFVKL |
| Biological Activity: | Determined by a cell proliferation assay using activated T cells. |
APRIL which is a part of the TNF ligand superfamily (TNFSF13) is a type II transmembrane protein. Normally, APRIL expression is low in tissues, but is elevated in numerous types of tumors and transformed cell lines. APRIL stimulates proliferation of tumor cell lines and intensifies tumorigenicity in nude mice.
APRIL Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 146 amino acids and having a molecular mass of 16.4 kDa. The APRIL is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TNFSF13: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. May be implicated in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. Belongs to the tumor necrosis factor family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytokine Cellular Component: extracellular space; membrane; cytoplasm; extracellular region; external side of plasma membrane Molecular Function:cytokine activity; tumor necrosis factor receptor binding Biological Process: regulation of immune response; immune system process; immunoglobulin production in mucosal tissue; positive regulation of cell proliferation; positive regulation of germinal center formation; immune response; immunoglobulin mediated immune response; positive regulation of isotype switching to IgA isotypes |
| UniProt Code: | Q9D777 |
| NCBI GenInfo Identifier: | 21363035 |
| NCBI Gene ID: | 69583 |
| NCBI Accession: | Q9D777.1 |
| UniProt Secondary Accession: | Q9D777,Q9ERP1, |
| UniProt Related Accession: | Q9D777 |
| Molecular Weight: | 26,889 Da |
| NCBI Full Name: | Tumor necrosis factor ligand superfamily member 13 |
| NCBI Synonym Full Names: | tumor necrosis factor (ligand) superfamily, member 13 |
| NCBI Official Symbol: | Tnfsf13�� |
| NCBI Official Synonym Symbols: | April; Tall2; Trdl1; 2310026N09Rik�� |
| NCBI Protein Information: | tumor necrosis factor ligand superfamily member 13; a proliferation-inducing ligand |
| UniProt Protein Name: | Tumor necrosis factor ligand superfamily member 13 |
| UniProt Synonym Protein Names: | A proliferation-inducing ligand; APRIL; CD_antigen: CD256 |
| UniProt Gene Name: | Tnfsf13�� |
| UniProt Entry Name: | TNF13_MOUSE |
Additional Information
Product Type: |
Recombinant Protein |
Species: |
Mouse |
Uniprot: |
Q9D777 |
Research Area: |
Cytokines |
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