Mouse ANXA5 Recombinant Protein (RPPB2756)

(No reviews yet) Write a Review
SKU:
RPPB2756

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Mouse ANXA5 Recombinant Protein
Product Code:RPPB2756
Size:20µg
Species:Mouse
Target:ANXA5
Synonyms:Annexin A5, ENX2, Placental Anticoagulant Protein 4, PlacentalAnticoagulant Protein I, Vascular Anticoagulant-Alpha, Thromboplastin Inhibitor, CalphobindinI, Anchorin CII, Endonexin II, Lipocortin V,Annexin V, Annexin-5, VAC-Alpha, RPRGL3, CBP-I, PAP-I, ANX5, PP4, EpididymisSecretory Protein Li 7, HEL-S-7.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:ANXA5 protein solution (1mg/ml) containing Phosphate Buffered Saline, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSP MGSMATRGTV TDFPGFDGRA DAEVLRKAMK GLGTDEDSIL NLLTSRSNAQ RQEIAQEFKT LFGRDLVDDL KSELTGKFEK LIVAMMKPSR LYDAYELKHA LKGAGTDEKV LTEIIASRTP EELSAIKQVY EEEYGSNLED DVVGDTSGYY QRMLVVLLQA NRDPDTAIDD AQVELDAQAL FQAGELKWGT DEEKFITIFG TRSVSHLRRV FDKYMTISGF QIEETIDRET SGNLEQLLLA VVKSIRSIPA YLAETLYYAM KGAGTDDHTL IRVVVSRSEI DLFNIRKEFR KNFATSLYSM IKGDTSGDYK KALLLLCGGE DD

ANXA5 is a member of the annexin family of calcium-dependent phospholipid binding proteins which are involved in membrane-related activity along exocytotic and endocytotic pathways. ANXA5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel properties and takes part in cellular signal transduction, inflammation, growth and differentiation. ANXA5 is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. ANXA5 regulates coagulability in the blood stream by binding to phosphatidylserine and sulfatide. ANXA5 protects sinsuoidal endothelial cells from ischemia reperfusion damage. ANXA5 is necessary for normal CFTR chloride channel activity.

ANXA5 Mouse Recombinant produced in E. coli is a single,non-glycosylated polypeptide chain containing 342 amino acids (1-319 a.a) andhaving a molecular mass of 38.1kDa.ANXA5 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:ANXA5: a calcium/phospholipid-binding protein and an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. The binding of labeled ANXA5 to phosphatidylserine is used as a marker of apoptosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.
UniProt Protein Details:

Protein type:Inhibitor; Calcium-binding; Lipid-binding; Apoptosis

Cellular Component: extracellular space; cell projection; focal adhesion; membrane; cytoplasm; plasma membrane; intracellular; Z disc; nucleus; sarcolemma; external side of plasma membrane

Molecular Function:protein binding; calcium-dependent phospholipid binding; peptide hormone binding; calcium ion binding; receptor tyrosine kinase binding

Biological Process: response to organic substance; hemostasis; positive regulation of apoptosis; negative regulation of blood coagulation; blood coagulation; negative regulation of coagulation; response to calcium ion; protein homooligomerization

UniProt Code:P48036
NCBI GenInfo Identifier:6753060
NCBI Gene ID:11747
NCBI Accession:NP_033803.1
UniProt Secondary Accession:P48036,Q3U5Q1, Q3U5X4, Q3U8K1, Q3UGV0, Q99LA1,
UniProt Related Accession:P48036
Molecular Weight:35,752 Da
NCBI Full Name:annexin A5
NCBI Synonym Full Names:annexin A5
NCBI Official Symbol:Anxa5��
NCBI Official Synonym Symbols:Anx5; R74653��
NCBI Protein Information:annexin A5; PP4; CBP-I; PAP-I; VAC-alpha; annexin V; annexin-5; anchorin CII; endonexin II; lipocortin V; calphobindin I; thromboplastin inhibitor; vascular anticoagulant-alpha; placental anticoagulant protein 4; placental anticoagulant protein I
UniProt Protein Name:Annexin A5
UniProt Synonym Protein Names:Anchorin CII; Annexin V; Annexin-5; Calphobindin I; CBP-I; Endonexin II; Lipocortin V; Placental anticoagulant protein 4; PP4; Placental anticoagulant protein I; PAP-I; Thromboplastin inhibitor; Vascular anticoagulant-alpha; VAC-alpha
Protein Family:Annexin
UniProt Gene Name:Anxa5��
UniProt Entry Name:ANXA5_MOUSE
View AllClose

Additional Information

Product Type:
Recombinant Protein
Species:
Mouse
Uniprot:
P48036
View AllClose

Related Products

Mouse CCL3 Recombinant Protein (RPES5168)
Quick view

Mouse CCL3 Recombinant Protein (RPES5168)

Chemokines Recombinant Proteins

system_update_altDatasheetMouse CCL3 Recombinant Protein C-C Motif Chemokine 3 (MIP-1 alpha,CCL3 ) is a member of the beta or CC subfamily of chemokines and is closely related to CCL4/MIP-1 beta.