Mouse ANXA5 Recombinant Protein (RPPB2756)
- SKU:
- RPPB2756
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P48036
Description
| Product Name: | Mouse ANXA5 Recombinant Protein |
| Product Code: | RPPB2756 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | ANXA5 |
| Synonyms: | Annexin A5, ENX2, Placental Anticoagulant Protein 4, PlacentalAnticoagulant Protein I, Vascular Anticoagulant-Alpha, Thromboplastin Inhibitor, CalphobindinI, Anchorin CII, Endonexin II, Lipocortin V,Annexin V, Annexin-5, VAC-Alpha, RPRGL3, CBP-I, PAP-I, ANX5, PP4, EpididymisSecretory Protein Li 7, HEL-S-7. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | ANXA5 protein solution (1mg/ml) containing Phosphate Buffered Saline, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSP MGSMATRGTV TDFPGFDGRA DAEVLRKAMK GLGTDEDSIL NLLTSRSNAQ RQEIAQEFKT LFGRDLVDDL KSELTGKFEK LIVAMMKPSR LYDAYELKHA LKGAGTDEKV LTEIIASRTP EELSAIKQVY EEEYGSNLED DVVGDTSGYY QRMLVVLLQA NRDPDTAIDD AQVELDAQAL FQAGELKWGT DEEKFITIFG TRSVSHLRRV FDKYMTISGF QIEETIDRET SGNLEQLLLA VVKSIRSIPA YLAETLYYAM KGAGTDDHTL IRVVVSRSEI DLFNIRKEFR KNFATSLYSM IKGDTSGDYK KALLLLCGGE DD |
ANXA5 is a member of the annexin family of calcium-dependent phospholipid binding proteins which are involved in membrane-related activity along exocytotic and endocytotic pathways. ANXA5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel properties and takes part in cellular signal transduction, inflammation, growth and differentiation. ANXA5 is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. ANXA5 regulates coagulability in the blood stream by binding to phosphatidylserine and sulfatide. ANXA5 protects sinsuoidal endothelial cells from ischemia reperfusion damage. ANXA5 is necessary for normal CFTR chloride channel activity.
ANXA5 Mouse Recombinant produced in E. coli is a single,non-glycosylated polypeptide chain containing 342 amino acids (1-319 a.a) andhaving a molecular mass of 38.1kDa.ANXA5 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ANXA5: a calcium/phospholipid-binding protein and an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. The binding of labeled ANXA5 to phosphatidylserine is used as a marker of apoptosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion. |
| UniProt Protein Details: | Protein type:Inhibitor; Calcium-binding; Lipid-binding; Apoptosis Cellular Component: extracellular space; cell projection; focal adhesion; membrane; cytoplasm; plasma membrane; intracellular; Z disc; nucleus; sarcolemma; external side of plasma membrane Molecular Function:protein binding; calcium-dependent phospholipid binding; peptide hormone binding; calcium ion binding; receptor tyrosine kinase binding Biological Process: response to organic substance; hemostasis; positive regulation of apoptosis; negative regulation of blood coagulation; blood coagulation; negative regulation of coagulation; response to calcium ion; protein homooligomerization |
| UniProt Code: | P48036 |
| NCBI GenInfo Identifier: | 6753060 |
| NCBI Gene ID: | 11747 |
| NCBI Accession: | NP_033803.1 |
| UniProt Secondary Accession: | P48036,Q3U5Q1, Q3U5X4, Q3U8K1, Q3UGV0, Q99LA1, |
| UniProt Related Accession: | P48036 |
| Molecular Weight: | 35,752 Da |
| NCBI Full Name: | annexin A5 |
| NCBI Synonym Full Names: | annexin A5 |
| NCBI Official Symbol: | Anxa5�� |
| NCBI Official Synonym Symbols: | Anx5; R74653�� |
| NCBI Protein Information: | annexin A5; PP4; CBP-I; PAP-I; VAC-alpha; annexin V; annexin-5; anchorin CII; endonexin II; lipocortin V; calphobindin I; thromboplastin inhibitor; vascular anticoagulant-alpha; placental anticoagulant protein 4; placental anticoagulant protein I |
| UniProt Protein Name: | Annexin A5 |
| UniProt Synonym Protein Names: | Anchorin CII; Annexin V; Annexin-5; Calphobindin I; CBP-I; Endonexin II; Lipocortin V; Placental anticoagulant protein 4; PP4; Placental anticoagulant protein I; PAP-I; Thromboplastin inhibitor; Vascular anticoagulant-alpha; VAC-alpha |
| Protein Family: | Annexin |
| UniProt Gene Name: | Anxa5�� |
| UniProt Entry Name: | ANXA5_MOUSE |
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