Enzymes Recombinant Proteins
Mouse AHCY Recombinant Protein (RPPB1364)
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- SKU:
- RPPB1364
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- P50247
- Research Area:
- Enzymes
Description
| Product Name: | Mouse AHCY Recombinant Protein |
| Product Code: | RPPB1364 |
| Size: | 20µg |
| Species: | Mouse |
| Target: | AHCY |
| Synonyms: | EC 3.3.1.1, SAHH, AdoHcyase, S-adenosyl-L-homocysteine hydrolase, Adenosylhomocysteinase. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | AHCY protein solution (0.25mg/ml) containing 20mM Tris-Hcl buffer (pH8.0) containing 40% glycerol 0.2M NaCl, 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMSDKLP YKVADIGLAA WGRKALDIAE NEMPGLMRMR EMYSASKPLK GARIAGCLHM TVETAVLIET LVALGAEVRW SSCNIFSTQD HAAAAIAKAG IPVFAWKGET DEEYLWCIEQ TLHFKDGPLN MILDDGGDLT NLIHTKYPQL LSGIRGISEE TTTGVHNLYK MMSNGILKVP AINVNDSVTK SKFDNLYGCR ESLIDGIKRA TDVMIAGKVA VVAGYGDVGK GCAQALRGFG ARVIITEIDP INALQAAMEG YEVTTMDEAC KEGNIFVTTT GCVDIILGRH FEQMKDDAIV CNIGHFDVEI DVKWLNENAV EKVNIKPQVD RYWLKNGRRI ILLAEGRLVN LGCAMGHPSF VMSNSFTNQV MAQIELWTHP DKYPVGVHFL PKKLDEAVAE AHLGKLNVKL TKLTEKQAQY LGMPINGPFK PDHYRY |
AHCY is an enzyme that catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). AHCY controls the intracellular S-adenosylhomocysteine (SAH) concentration that is crucial for transmethylation reactions. AHCY deficiency causes hypermethioninemia.
AHCY Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 456 amino acids (1-432 a.a) and having a molecular mass of 50.2kDa.AHCY is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. |
| UniProt Code: | P50247 |
| NCBI GenInfo Identifier: | 21431841 |
| NCBI Gene ID: | 11615 |
| NCBI Accession: | P50247.3 |
| UniProt Secondary Accession: | P50247,Q91WF1, |
| Molecular Weight: | 47,688 Da |
| NCBI Full Name: | Adenosylhomocysteinase |
| NCBI Synonym Full Names: | predicted gene 4737 |
| NCBI Official Symbol: | Gm4737�� |
| NCBI Official Synonym Symbols: | EG11615; AL024110�� |
| NCBI Protein Information: | predicted gene 4737 |
| UniProt Protein Name: | Adenosylhomocysteinase |
| UniProt Synonym Protein Names: | CUBP; Liver copper-binding protein; S-adenosyl-L-homocysteine hydrolase |
| Protein Family: | Adenosylhomocysteinase |
| UniProt Gene Name: | Ahcy�� |
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