Mouse Activin RIIA/ACVR2A Recombinant Protein (RPES2170)
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- SKU:
- RPES2170
- Product Type:
- Recombinant Protein
- Species:
- Mouse
Description
system_update_altDatasheet
Mouse Activin RIIA/ACVR2A Recombinant Protein
ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately 98% identity) to the rat, mouse, and human ACVR2A proteins. Inactivation of ACVR2A is a common event in prostate cancer cells suggesting it may play an important role in the development of prostate cancer. The ACVR2A gene is a putative tumor suppressor gene that is frequently mutated in microsatellite-unstable colon cancers (MSI-H colon cancers). Frameshift mutation of ACVR2A may contribute to MSI-H colon tumorigenesis via disruption of alternate TGF-beta effector pathways.
| Product Name: | Mouse Activin RIIA/ACVR2A Recombinant Protein (RPES2170) |
| Product Code: | RPES2170 |
| Size: | 100µg |
| Species: | Mouse |
| Expressed Host: | HEK293 Cells |
| Synonyms: | ActrIIa,Acvr2,TactrII |
| Accession: | NP_031422.3 |
| Sequence: | Met 1-Pro 134 |
| Fusion tag: | C-His-Fc |
| Activity: | Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation.The ED50 for this effect is typically 20-60 ng/mL in the presence of 10 ng/mL recombinant Activin A. |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the extracellular domain of mouse ACVR2A (NP_031422.3) (Met 1-Pro 134) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus. |
| Purity: | > 97 % as determined by SDS-PAGE |
| Mol Mass: | 41.4 kDa |
| AP Mol Mass: | 55-65 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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