MNT Antibody (PACO22724)
- SKU:
- PACO22724
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MNT Antibody (PACO22724) |
| Antibody SKU: | PACO22724 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human MNT. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from A549 cells, using MNT antibody. |
| Background: | Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'. |
| Synonyms: | Max-binding protein MNT; Protein ROX; Myc antagonist MNT; MNT; ROX |
| UniProt Protein Function: | MNT: Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 17p13.3Cellular Component: nucleoplasm; nucleusMolecular Function: protein dimerization activity; transcription coactivator activity; chromatin binding; transcription factor activity; transcription corepressor activityBiological Process: transcription from RNA polymerase II promoter; negative regulation of cell proliferation; regulation of cell cycle; multicellular organismal development; cell aging; negative regulation of transcription from RNA polymerase II promoter |
| UniProt Protein Details: | |
| NCBI Summary: | The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99583 |
| NCBI GenInfo Identifier: | 9945318 |
| NCBI Gene ID: | 4335 |
| NCBI Accession: | NP_064706.1 |
| UniProt Secondary Accession: | Q99583,Q1ED38, A8K6D1, D3DTI7 |
| UniProt Related Accession: | Q99583 |
| Molecular Weight: | 62,300 Da |
| NCBI Full Name: | max-binding protein MNT |
| NCBI Synonym Full Names: | MAX network transcriptional repressor |
| NCBI Official Symbol: | MNT |
| NCBI Official Synonym Symbols: | ROX; MAD6; MXD6; bHLHd3 |
| NCBI Protein Information: | max-binding protein MNT; myc antagonist MNT; MAX binding protein; Max-interacting protein; MNT, MAX dimerization protein; class D basic helix-loop-helix protein 3 |
| UniProt Protein Name: | Max-binding protein MNT |
| UniProt Synonym Protein Names: | Class D basic helix-loop-helix protein 3; bHLHd3; Myc antagonist MNT; Protein ROX |
| Protein Family: | Max-binding protein |
| UniProt Gene Name: | MNT |
| UniProt Entry Name: | MNT_HUMAN |
| Antibodies |
| MNT Antibody (PACO06648) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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