Antibody Name:	MNDA Antibody (PACO22433)
Antibody SKU:	PACO22433
Size:	100ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:	Human
Immunogen:	Synthesized peptide derived from C-terminal of human MNDA.

Form:	Liquid
Storage Buffer:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Western blot analysis of extracts from LOVO cells, using MNDA antibody.

Background:

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.

Synonyms:

myeloid cell nuclear differentiation antigen; PYHIN3;

UniProt Protein Function:	May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.
NCBI Summary:	The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]
UniProt Code:	P41218
NCBI GenInfo Identifier:	730038
NCBI Gene ID:	4332
NCBI Accession:	P41218.1
UniProt Related Accession:	P41218
Molecular Weight:	407
NCBI Full Name:	Myeloid cell nuclear differentiation antigen
NCBI Synonym Full Names:	myeloid cell nuclear differentiation antigen
NCBI Official Symbol:	MNDA
NCBI Official Synonym Symbols:	PYHIN3
NCBI Protein Information:	myeloid cell nuclear differentiation antigen
UniProt Protein Name:	Myeloid cell nuclear differentiation antigen
Protein Family:	Myeloid cell nuclear differentiation antigen
UniProt Gene Name:	MNDA
UniProt Entry Name:	MNDA_HUMAN

Antibodies	ELISA Kits
MNDA Antibody (PACO02908)	Human MNDA / Myeloid cell nuclear differentiation ELISA Kit
MNDA Antibody (PACO10534)	Human Myeloid cell nuclear differentiation antigen (MNDA) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)