| UniProt Protein Function: | May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1. |
| NCBI Summary: | The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P41218 |
| NCBI GenInfo Identifier: | 730038 |
| NCBI Gene ID: | 4332 |
| NCBI Accession: | P41218.1 |
| UniProt Related Accession: | P41218 |
| Molecular Weight: | 407 |
| NCBI Full Name: | Myeloid cell nuclear differentiation antigen |
| NCBI Synonym Full Names: | myeloid cell nuclear differentiation antigen |
| NCBI Official Symbol: | MNDA |
| NCBI Official Synonym Symbols: | PYHIN3 |
| NCBI Protein Information: | myeloid cell nuclear differentiation antigen |
| UniProt Protein Name: | Myeloid cell nuclear differentiation antigen |
| Protein Family: | Myeloid cell nuclear differentiation antigen |
| UniProt Gene Name: | MNDA |
| UniProt Entry Name: | MNDA_HUMAN |
