| UniProt Protein Function: | MN1: May play a role in tumor suppression. A chromosomal aberration involving MN1 may be a cause of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with TEL. Defects in MN1 involved in the development of meningiomas, slowly growing benign tumors derived from the arachnoidal cap cells of the leptomeninges, the soft coverings of the brain and spinal cord. Meningiomas are believed to be the most common primary tumors of the central nervous system in man. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; Nuclear receptor co-regulator; Tumor suppressor Chromosomal Location of Human Ortholog: 22q12.1 Disease: Meningioma, Familial, Susceptibility To |
| NCBI Summary: | Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q10571 |
| NCBI GenInfo Identifier: | 215274133 |
| NCBI Gene ID: | 4330 |
| NCBI Accession: | Q10571.3 |
| UniProt Secondary Accession: | Q10571,A9Z1V9, |
| UniProt Related Accession: | Q10571 |
| Molecular Weight: | 136,001 Da |
| NCBI Full Name: | Transcriptional activator MN1 |
| NCBI Synonym Full Names: | MN1 proto-oncogene, transcriptional regulator |
| NCBI Official Symbol: | MN1 |
| NCBI Official Synonym Symbols: | MGCR; MGCR1; MGCR1-PEN; dJ353E16.2 |
| NCBI Protein Information: | transcriptional activator MN1 |
| UniProt Protein Name: | Transcriptional activator MN1 |
| UniProt Synonym Protein Names: | Probable tumor suppressor protein MN1Curated |
| Protein Family: | Transcriptional activator |
| UniProt Gene Name: | MN1 |
| UniProt Entry Name: | MN1_HUMAN |
