Name: MMP24 Antibody (PACO18240)
SKU: PACO18240
Availability: OutOfStock

Antibody Name:	MMP24 Antibody (PACO18240)
Antibody SKU:	PACO18240
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB
Recommended Dilutions:	ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human MMP24

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Gel: 6%SDS-PAGE,Lysate: 40 μg,Lane 1-2: 293T cells, HepG2 cells,Primary antibody: PACO18240(MMP24 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 40 seconds.

Background:	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases.
Synonyms:	matrix metallopeptidase 24 (membrane-inserted)

UniProt Protein Function:	MMP24: Activates progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin. Belongs to the peptidase M10A family.
UniProt Protein Details:	Protein type:Membrane protein, integral; EC 3.4.24.-; Activator; Protease Chromosomal Location of Human Ortholog: 20q11.2 Cellular Component: proteinaceous extracellular matrix; integral to plasma membrane; trans-Golgi network membrane Molecular Function:zinc ion binding; cadherin binding; metalloendopeptidase activity; enzyme activator activity; calcium ion binding Biological Process: positive regulation of catalytic activity; glial cell differentiation; proteolysis; detection of temperature stimulus involved in sensory perception of pain
NCBI Summary:	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9Y5R2
NCBI GenInfo Identifier:	12585280
NCBI Gene ID:	10893
NCBI Accession:	Q9Y5R2.1
UniProt Secondary Accession:	Q9Y5R2,Q9H440, B7ZBG8,
UniProt Related Accession:	Q9Y5R2
Molecular Weight:
NCBI Full Name:	Matrix metalloproteinase-24
NCBI Synonym Full Names:	matrix metallopeptidase 24 (membrane-inserted)
NCBI Official Symbol:	MMP24
NCBI Official Synonym Symbols:	MMP25; MMP-24; MT5MMP; MTMMP5; MT-MMP5; MT5-MMP; MT-MMP 5
NCBI Protein Information:	matrix metalloproteinase-24; membrane-type 5 matrix metalloproteinase; membrane-type matrix metalloproteinase 5; membrane-type-5 matrix metalloproteinase; matrix metalloproteinase 24 (membrane-inserted)
UniProt Protein Name:	Matrix metalloproteinase-24
UniProt Synonym Protein Names:	Membrane-type matrix metalloproteinase 5; MT-MMP 5; MTMMP5; Membrane-type-5 matrix metalloproteinase; MT5-MMP; MT5MMP
Protein Family:	Matrix metalloproteinase
UniProt Gene Name:	MMP24
UniProt Entry Name:	MMP24_HUMAN