UniProt Protein Function: | MMP24: Activates progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin. Belongs to the peptidase M10A family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; EC 3.4.24.-; Activator; Protease Chromosomal Location of Human Ortholog: 20q11.2 Cellular Component: proteinaceous extracellular matrix; integral to plasma membrane; trans-Golgi network membrane Molecular Function:zinc ion binding; cadherin binding; metalloendopeptidase activity; enzyme activator activity; calcium ion binding Biological Process: positive regulation of catalytic activity; glial cell differentiation; proteolysis; detection of temperature stimulus involved in sensory perception of pain |
NCBI Summary: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9Y5R2 |
NCBI GenInfo Identifier: | 12585280 |
NCBI Gene ID: | 10893 |
NCBI Accession: | Q9Y5R2.1 |
UniProt Secondary Accession: | Q9Y5R2,Q9H440, B7ZBG8, |
UniProt Related Accession: | Q9Y5R2 |
Molecular Weight: | |
NCBI Full Name: | Matrix metalloproteinase-24 |
NCBI Synonym Full Names: | matrix metallopeptidase 24 (membrane-inserted) |
NCBI Official Symbol: | MMP24 |
NCBI Official Synonym Symbols: | MMP25; MMP-24; MT5MMP; MTMMP5; MT-MMP5; MT5-MMP; MT-MMP 5 |
NCBI Protein Information: | matrix metalloproteinase-24; membrane-type 5 matrix metalloproteinase; membrane-type matrix metalloproteinase 5; membrane-type-5 matrix metalloproteinase; matrix metalloproteinase 24 (membrane-inserted) |
UniProt Protein Name: | Matrix metalloproteinase-24 |
UniProt Synonym Protein Names: | Membrane-type matrix metalloproteinase 5; MT-MMP 5; MTMMP5; Membrane-type-5 matrix metalloproteinase; MT5-MMP; MT5MMP |
Protein Family: | Matrix metalloproteinase |
UniProt Gene Name: | MMP24 |
UniProt Entry Name: | MMP24_HUMAN |