MMP2 Monoclonal Antibody
- SKU:
- CAB23496
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | MMP2 Monoclonal Antibody |
| Product Code: | CAB23496 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC57602 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:1000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | U-87MG, C2C12, Rat lung |
| Cellular Location: | Cytoplasm, Membrane, Mitochondrion, Nucleus, Secreted, extracellular matrix, extracellular space |
This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 451-660 of human MMP2(NP_004521.1). |
| Sequence: | ATTGA CCTTG GCACC GGCCC CACCC CCACG CTGGG CCCTG TCACT CCTGA GATCT GCAAA CAGGA CATTG TATTT GATGG CATCG CTCAG ATCCG TGGTG AGATC TTCTT CTTCA AGGAC CGGTT CATTT GGCGG ACTGT GACGC CACGT GACAA GCCCA TGGGG CCCCT GCTGG TGGCC ACATT CTGGC CTGAG CTCCC GGAAA AGATT GATGC GGTAT ACGAG GCCCC ACAGG AGGAG AAGGC TGTGT TCTTT GCAGG GAATG AATAC TGGAT CTACT CAGCC AGCAC CCTGG AGCGA GGGTA CCCCA AGCCA CTGAC CAGCC TGGGA CTGCC CCCTG ATGTC CAGCG AGTGG ATGCC GCCTT TAACT GGAGC AAAAA CAAGA AGACA TACAT CTTTG CTGGA GACAA ATTCT GGAGA TACAA TGAGG TGAAG AAGAA AATGG ATCCT GGCTT CCCCA AGCTC ATCGC AGATG CCTGG AATGC CATCC CCGAT AACCT GGATG CCGTC GTGGA CCTGC AGGGC GGCGG TCACA GCTAC TTCTT CAAGG GTGCC TATTA CCTGA AGCTG GAGAA CCAAA GTCTG AAGAG CGTGA AGTTT GGAAG CATCA AATCC GACTG GCTAG GCTGC |
| Synonyms: | CLG4 |
| Calculated MW: | 74kDa |
| Observed MW: | 64kDa/72kDa |
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