Antibody Name:	Mmp2 Antibody (PACO28294)
Antibody SKU:	PACO28294
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA
Recommended Dilutions:
Species Reactivity:	Rat
Immunogen:	Recombinant Rat 72 kDa type IV collagenase protein (110-662AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Background:

Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- |-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3β in vitro. Involved in the formation of the fibrovascular tissues (By similarity).

Synonyms:

72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) [Cleaved into: PEX], Mmp2

UniProt Protein Function:	Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-\|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues.
NCBI Summary:	plays important roles in wound healing, angiogenesis, platelet aggregation, and tumor metastasis; mediates the response of the intrinsic glomerular mesangial cell to inflammatory stimuli [RGD, Feb 2006]
UniProt Code:	P33436
NCBI GenInfo Identifier:	146345459
NCBI Gene ID:	81686
NCBI Accession:	P33436.2
UniProt Secondary Accession:	P33436,P97581, Q6GMM9,
UniProt Related Accession:	P33436
Molecular Weight:	74,149 Da
NCBI Full Name:	72 kDa type IV collagenase
NCBI Synonym Full Names:	matrix metallopeptidase 2
NCBI Official Symbol:	Mmp2
NCBI Protein Information:	72 kDa type IV collagenase; MMP-2; gelatinase A; 72 kDa gelatinase; matrix metalloproteinase 2; matrix metalloproteinase-2
UniProt Protein Name:	72 kDa type IV collagenase
UniProt Synonym Protein Names:	72 kDa gelatinase; Gelatinase A; Matrix metalloproteinase-2; MMP-2
Protein Family:	Matrix metalloproteinase
UniProt Gene Name:	Mmp2
UniProt Entry Name:	MMP2_RAT