Description
| Product Name: | MMP13 Monoclonal Antibody |
| Product Code: | CAB22334 |
| Reactivity: | Human |
| Applications: | Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC51250 |
| Reactivity: | Human |
| Tested Applications: | IF/ICC, ELISA |
| Key Applications: | Immunofluorescence |
| Recommended Dilution: | IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 104-272 of human MMP13 (NP_002418.1). |
| Sequence: | YNVFP RTLKW SKMNL TYRIV NYTPD MTHSE VEKAF KKAFK VWSDV TPLNF TRLHD GIADI MISFG IKEHG DFYPF DGPSG LLAHA FPPGP NYGGD AHFDD DETWT SSSKG YNLFL VAAHE FGHSL GLDHS KDPGA LMFPI YTYTG KSHFM LPDDD VQGIQ SLYGP GDED |
| Synonyms: | CLG3, MDST, MANDP1, MMP-13 |
| Calculated MW: | 54kDa |
| Observed MW: | Refer to figures |
![Anti-MMP13 Antibody (CAB16920)[KO Validated]](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/590x590/products/44132/48877/anti-mmp13-antibody-cab16920ko-validated__77199__65721.1706523712.jpg?c=1 "Anti-MMP13 Antibody (CAB16920)[KO Validated]")