MMP1 Monoclonal Antibody
- SKU:
- CAB22080
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | MMP1 Monoclonal Antibody |
| Product Code: | CAB22080 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC55239 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:2000-1:20000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | A-375, SK-OV-3, Mouse bone, Rat spleen |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
| Customer Validation: | WB(Homo sapiens) |
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 93-210 of human MMP1 (NP_002412.1). |
| Sequence: | GVPDV AQFVL TEGNP RWEQT HLTYR IENYT PDLPR ADVDH AIEKA FQLWS NVTPL TFTKV SEGQA DIMIS FVRGD HRDNS PFDGP GGNLA HAFQP GPGIG GDAHF DEDER WTNNF REY |
| Synonyms: | CLG, CLGN |
| Calculated MW: | 54kDa |
| Observed MW: | 62kDa |
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