MLKL Polyclonal Antibody
_KO-WB_01__15207__19825.1706547544.jpg?c=1 "MLKL Polyclonal Antibody")
- SKU:
- CAB23063
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
_KO-WB_01__15207__19825.1706547544.jpg?c=1&imbypass=on "MLKL Polyclonal Antibody")
Description
| Product Name: | MLKL Polyclonal Antibody |
| Product Code: | CAB23063 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa |
| Cellular Location: | Cell membrane, Cytoplasm |
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 179-471 of human MLKL. (NP_689862.1). |
| Sequence: | YLPPK CMQEI PQEQI KEIKK EQLSG SPWIL LRENE VSTLY KGEYH RAPVA IKVFK KLQAG SIAIV RQTFN KEIKT MKKFE SPNIL RIFGI CIDET VTPPQ FSIVM EYCEL GTLRE LLDRE KDLTL GKRMV LVLGA ARGLY RLHHS EAPEL HGKIR SSNFL VTQGY QVKLA GFELR KTQTS MSLGT TREKT DRVKS TAYLS PQELE DVFYQ YDVKS EIYSF GIVLW EIATG DIPFQ GCNSE KIRKL VAVKR QQEPL GEDCP SELRE IIDEC RAHDP SVRPS VDEIL KKLST FSK |
| Synonyms: | hMLKL |
| Calculated MW: | 54kDa |
| Observed MW: | 54kDa |
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![Anti-MLKL Antibody (CAB13451)[KO Validated]](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/590x590/products/40763/45508/anti-mlkl-antibody-cab13451ko-validated__79871__53808.1706521997.jpg?c=1 "Anti-MLKL Antibody (CAB13451)[KO Validated]")