MLKL Monoclonal Antibody
- SKU:
- CAB21894
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | MLKL Monoclonal Antibody |
| Product Code: | CAB21894 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC2471 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:500-1:2000, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HepG2, NIH/3T3, HUVEC, Mouse liver, Mouse thymus, Rat liver |
| Cellular Location: | Cell membrane, Cytoplasm, Nucleus |
| Customer Validation: | WB(Mus musculus) |
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 10-193 of human MLKL (Q8NB16). |
| Sequence: | LGQVI HKRCE EMKYC KKQCR RLGHR VLGLI KPLEM LQDQG KRSVP SEKLT TAMNR FKAAL EEANG EIEKF SNRSN ICRFL TASQD KILFK DVNRK LSDVW KELSL LLQVE QRMPV SPISQ GASWA QEDQQ DADED RRAFQ MLRRD NEKIE ASLRR LEINM KEIKE TLRQY LPPKC MQEIP QEQI |
| Synonyms: | hMLKL |
| Calculated MW: | 54kDa |
| Observed MW: | 54kDa |
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