MLH1 Polyclonal Antibody
- SKU:
- CAB21491
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | MLH1 Polyclonal Antibody |
| Product Code: | CAB21491 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Cellular Location: | Nucleus |
The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC).
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human MLH1 (NP_000240.1). |
| Sequence: | PGLAG PSGEM VKSTT SLTSS STSGS SDKVY AHQMV RTDSR EQKLD AFLQP LSKPL SSQPQ AIVTE DKTDI SSGRA RQQDE EMLEL PAPAE VAAKN QSLEG D |
| Synonyms: | FCC2, COCA2, HNPCC, MLH-1, hMLH1, HNPCC2, LYNCH2, MMRCS1 |
| Calculated MW: | 85kDa |
| Observed MW: | Refer to figures |
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