MKP1 Polyclonal Antibody (CAB24667)
- SKU:
- CAB24667
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | MKP1 Polyclonal Antibody |
| Product Code: | CAB24667 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:100-1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa |
| Cellular Location: | Nucleus |
The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 267-367 of human MKP1 (NP_004408.1). |
| Sequence: | TICLA YLMRT NRVKL DEAFE FVKQR RSIIS PNFSF MGQLL QFESQ VLAPH CSAEA GSPAM AVLDR GTSTT TVFNF PVSIP VHSTN SALSY LQSPI TTSPS C |
| Synonyms: | HVH1, MKP1, CL100, MKP-1, PTPN10 |
| Calculated MW: | 39kDa |
| Observed MW: | 40kDa |
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