MICAL2 Antibody (PACO28238)
- SKU:
- PACO28238
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MICAL2 Antibody (PACO28238) |
| Antibody SKU: | PACO28238 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human [F-actin]-monooxygenase MICAL2 protein (1-495AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO28238 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO28238 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA. |
| Synonyms: | [F-actin]-monooxygenase MICAL2 (EC 1.14.13.225) (Molecule interacting with CasL protein 2) (MICAL-2), MICAL2, KIAA0750 MICAL2PV1 MICAL2PV2 |
| UniProt Protein Function: | MICAL2: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Belongs to the Mical family. 6 isoforms of the human protein are produced by alternative splicing.Protein type: EC 1.14.13.-; Adaptor/scaffoldChromosomal Location of Human Ortholog: 11p15.3Cellular Component: nucleusMolecular Function: actin binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygenBiological Process: actin filament depolymerization; cytoskeleton organization and biogenesis; heart development; heart looping; sulfur oxidation |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | O94851 |
| NCBI GenInfo Identifier: | 46396148 |
| NCBI Gene ID: | 9645 |
| NCBI Accession: | O94851.1 |
| UniProt Secondary Accession: | O94851,Q5KTR3, Q5KTR4, Q7Z3A8, B4DGZ0, B7Z849, D3DQW5 G3XAC8 |
| UniProt Related Accession: | O94851 |
| Molecular Weight: | 109,216 Da |
| NCBI Full Name: | Protein-methionine sulfoxide oxidase MICAL2 |
| NCBI Synonym Full Names: | microtubule associated monooxygenase, calponin and LIM domain containing 2 |
| NCBI Official Symbol: | MICAL2 |
| NCBI Official Synonym Symbols: | MICAL-2; MICAL2PV1; MICAL2PV2 |
| NCBI Protein Information: | protein-methionine sulfoxide oxidase MICAL2 |
| UniProt Protein Name: | Protein-methionine sulfoxide oxidase MICAL2 |
| UniProt Synonym Protein Names: | Molecule interacting with CasL protein 2; MICAL-2 |
| Protein Family: | Protein-methionine sulfoxide oxidase |
| UniProt Gene Name: | MICAL2 |
| UniProt Entry Name: | MICA2_HUMAN |
| Antibodies |
| MICAL2 Antibody (PACO10489) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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