MFNG Antibody (PACO04325)
- SKU:
- PACO04325
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MFNG Antibody |
| Antibody SKU: | PACO04325 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human Manic Fringe. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | MFNG; Beta-1; 3-N-acetylglucosaminyltransferase manic fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
| UniProt Protein Function: | MFNG: Glycosyltransferase involved in the elongation of O- linked ligands to activate Notch signaling. Possesses fucose- specific beta-1,3-N-acetylglucosaminyltransferase activity. Belongs to the glycosyltransferase 31 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transferase; Membrane protein, integral; EC 2.4.1.222Chromosomal Location of Human Ortholog: 22q12Cellular Component: extracellular space; integral to Golgi membraneMolecular Function: metal ion binding; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activityBiological Process: positive regulation of protein binding; metabolic process; pattern specification process; positive regulation of Notch signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | This gene is a member of the glycosyltransferase 31 gene family. Members of this gene family, which also includes the LFNG (GeneID: 3955) and RFNG (GeneID: 5986) genes, encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, these proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. The protein encoded by this gene may control Notch signaling in claudin-low breast cancer. [provided by RefSeq, May 2018] |
| UniProt Code: | O00587 |
| NCBI GenInfo Identifier: | 21536461 |
| NCBI Gene ID: | 4242 |
| NCBI Accession: | NP_002396 |
| UniProt Secondary Accession: | O00587 |
| UniProt Related Accession: | O00587 |
| Molecular Weight: | 36kDa |
| NCBI Full Name: | beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform 1 |
| NCBI Synonym Full Names: | MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
| NCBI Official Symbol: | MFNG |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | beta-1,3-N-acetylglucosaminyltransferase manic fringe |
| UniProt Protein Name: | Beta-1,3-N-acetylglucosaminyltransferase manic fringe |
| UniProt Synonym Protein Names: | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
| Protein Family: | Beta-1,3-N-acetylglucosaminyltransferase manic fringe |
| UniProt Gene Name: | MFNG |
| UniProt Entry Name: | MFNG_HUMAN |
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