Metrnl Antibody (PACO52702)
- SKU:
- PACO52702
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Metrnl Antibody (PACO52702) |
| Antibody SKU: | PACO52702 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:200-1:2000 |
| Species Reactivity: | Mouse, Rat |
| Immunogen: | Recombinant Mouse Meteorin-like protein (46-311AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Rat brain tissue. All lanes: Metrnl antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 35, 36 kDa. Observed band size: 35 kDa. |
| Background: | Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures. |
| Synonyms: | Meteorin-like protein (Subfatin), Metrnl |
| UniProt Protein Function: | METRNL: Belongs to the meteorin family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Cellular Component: extracellular space; extracellular region Molecular Function:hormone activity Biological Process: fat cell differentiation; response to muscle activity; negative regulation of inflammatory response; brown fat cell differentiation; response to cold |
| UniProt Code: | Q8VE43 |
| NCBI GenInfo Identifier: | 21450153 |
| NCBI Gene ID: | 210029 |
| NCBI Accession: | NP_659046.1 |
| UniProt Secondary Accession: | Q8VE43,Q8R1J2, |
| UniProt Related Accession: | Q8VE43 |
| Molecular Weight: | 34,530 Da |
| NCBI Full Name: | meteorin-like protein |
| NCBI Synonym Full Names: | meteorin, glial cell differentiation regulator-like |
| NCBI Official Symbol: | Metrnl |
| NCBI Official Synonym Symbols: | BC019776; 9430048M07Rik |
| NCBI Protein Information: | meteorin-like protein; cometin |
| UniProt Protein Name: | Meteorin-like protein |
| UniProt Synonym Protein Names: | Subfatin |
| Protein Family: | Meteorin-like protein |
| UniProt Gene Name: | Metrnl |
| UniProt Entry Name: | METRL_MOUSE |
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