Merlin Polyclonal Antibody
- SKU:
- CAB22558
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Merlin Polyclonal Antibody |
| Product Code: | CAB22558 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:100-1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | Jurkat, MCF7, HeLa |
| Cellular Location: | cortical actin cytoskeleton, cytoplasm, cytoskeleton, cytosol, early endosome, filopodium membrane, nucleolus, nucleus, perinuclear region of cytoplasm, plasma membrane, ruffle membrane |
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that link cytoskeletal components with proteins in the cell membrane. The encoded protein is involved in regulation of contact-dependent inhibition of cell proliferation and functions in cell-cell adhesion and transmembrane signaling. The encoded protein has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics, and proteins involved in regulating ion transport. Disruption of this protein's function has been implicated in tumorigenesis and metastasis. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 347-595 of human Merlin. (NP_000259.1). |
| Sequence: | EEAER TRDEL ERRLL QMKEE ATMAN EALMR SEETA DLLAE KAQIT EEEAK LLAQK AAEAE QEMQR IKATA IRTEE EKRLM EQKVL EAEVL ALKMA EESER RAKEA DQLKQ DLQEA REAER RAKQK LLEIA TKPTY PPMNP IPAPL PPDIP SFNLI GDSLS FDFKD TDMKR LSMEI EKEKV EYMEK SKHLQ EQLNE LKTEI EALKL KERET ALDIL HNENS DRGGS SKHNT IKKLT LQSAK SRVAF FEEL |
| Synonyms: | ACN, SCH, BANF, merlin-1 |
| Calculated MW: | 70kDa |
| Observed MW: | 75kDa |
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