MEOX1 Antibody (PACO44657)
- SKU:
- PACO44657
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MEOX1 Antibody (PACO44657) |
| Antibody SKU: | PACO44657 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Homeobox protein MOX-1 protein (1-254AA) |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO44657 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using PACO44657 at dilution of 1:100. |
| Background: | Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. |
| Synonyms: | Homeobox protein MOX-1 (Mesenchyme homeobox 1), MEOX1, MOX1 |
| UniProt Protein Function: | MEOX1: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor Chromosomal Location of Human Ortholog: 17q21 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; sequence-specific DNA binding; transcription factor activity Biological Process: multicellular organismal development Disease: Klippel-feil Syndrome 2, Autosomal Recessive |
| NCBI Summary: | This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P50221 |
| NCBI GenInfo Identifier: | 1709078 |
| NCBI Gene ID: | 4222 |
| NCBI Accession: | P50221.1 |
| UniProt Secondary Accession: | P50221,Q15069, A8K524, A8MWF9, |
| UniProt Related Accession: | P50221 |
| Molecular Weight: | 15,628 Da |
| NCBI Full Name: | Homeobox protein MOX-1 |
| NCBI Synonym Full Names: | mesenchyme homeobox 1 |
| NCBI Official Symbol: | MEOX1 |
| NCBI Official Synonym Symbols: | KFS2; MOX1 |
| NCBI Protein Information: | homeobox protein MOX-1 |
| UniProt Protein Name: | Homeobox protein MOX-1 |
| UniProt Synonym Protein Names: | Mesenchyme homeobox 1 |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | MEOX1 |
| UniProt Entry Name: | MEOX1_HUMAN |
| Antibodies |
| Anti-MEOX1 Antibody (CAB7332) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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