MEIKIN Antibody (PACO47846)
- SKU:
- PACO47846
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MEIKIN Antibody (PACO47846) |
| Antibody SKU: | PACO47846 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Meiosis-specific kinetochore protein (18-91AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO47846 at dilution of 1:100. |
| Background: | Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis. |
| Synonyms: | Meiosis-specific kinetochore protein, MEIKIN |
| UniProt Protein Function: | MEIKIN: Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase- mediated cleavage. Acts by facilitating kinetochore mono- orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichemnt to kinetochores. Not required during meiosis II or mitosis. {ECO:0000250|UniProtKB:Q5F2C3}. Interacts with CENPC. Interacts with PLK1; required for recruitment of PLK1 at kinetochores. {ECO:0000250|UniProtKB:Q5F2C3}Chromosomal Location of Human Ortholog: 5q31.1Cellular Component: condensed nuclear chromosome, pericentric regionBiological Process: female meiosis chromosome segregation; homologous chromosome segregation; male meiosis chromosome segregation; meiotic sister chromatid cohesion, centromeric |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | A0A087WXM9 |
| NCBI GenInfo Identifier: | 765490678 |
| NCBI Gene ID: | 728637 |
| NCBI Accession: | A0A087WXM9 |
| UniProt Secondary Accession: | A0A087WXM9,A0A0A8IBZ9 |
| UniProt Related Accession: | A0A087WXM9 |
| Molecular Weight: | 40,829 Da |
| NCBI Full Name: | Meiosis-specific kinetochore protein |
| NCBI Synonym Full Names: | meiotic kinetochore factor |
| NCBI Official Symbol: | MEIKIN |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | meiosis-specific kinetochore protein |
| UniProt Protein Name: | Meiosis-specific kinetochore protein |
| UniProt Synonym Protein Names: | |
| Protein Family: | Meiosis-specific kinetochore protein |
| UniProt Gene Name: | MEIKIN |
| UniProt Entry Name: | MEIKN_HUMAN |
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