Megalin/LRP2 Monoclonal Antibody
- SKU:
- CAB24690
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
Description
| Product Name: | Megalin/LRP2 Monoclonal Antibody |
| Product Code: | CAB24690 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC63830 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, IF/ICC, FC, FC(Intra), ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:50-1:200, IF/ICC 1:50-1:200, FC(Intra) 1:100-1:500 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse kidney |
| Cellular Location: | Membrane, Single-pass type I membrane protein, coated pit |
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 4446-4655 of human Megalin/LRP2（NP_004516.2）. |
| Sequence: | FHYRR TGSLL PALPK LPSLS SLVKP SENGN GVTFR SGADL NMDIG VSGFG PETAI DRSMA MSEDF VMEMG KQPII FENPM YSARD SAVKV VQPIQ VTVSE NVDNK NYGSP INPSE IVPET NPTSP AADGT QVTKW NLFKR KSKQT TNFEN PIYAQ MENEQ KESVA ATPPP SPSLP AKPKP PSRRD PTPTY SATED TFKDT ANLVK EDSEV |
| Synonyms: | DBS, GP330, LRP-2 |
| Calculated MW: | 522kDa |
| Observed MW: | 250kDa+ |
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