MED26 Antibody (PACO61562)
- SKU:
- PACO61562
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MED26 Antibody (PACO61562) |
| Antibody SKU: | PACO61562 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:500-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Mediator of RNA polymerase II transcription subunit 26 protein (372-523AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO61562 diluted at 1:500 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. |
| Synonyms: | Mediator of RNA polymerase II transcription subunit 26, Activator-recruited cofactor 70 kDa component, ARC70, Cofactor required for Sp1 transcriptional activation subunit 7, CRSP complex subunit 7, Mediator complex subunit 26, Transcriptional coactivator CRSP70, MED26, ARC70, CRSP7 |
| UniProt Protein Function: | MED26: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 26 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: nucleoplasm; Srb-mediator complex Molecular Function:protein binding; transcription coactivator activity Biological Process: regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter |
| NCBI Summary: | The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95402 |
| NCBI GenInfo Identifier: | 158931130 |
| NCBI Gene ID: | 9441 |
| NCBI Accession: | O95402.2 |
| UniProt Secondary Accession: | O95402,Q0VGB6, A1A4S3, |
| UniProt Related Accession: | O95402 |
| Molecular Weight: | 10,359 Da |
| NCBI Full Name: | Mediator of RNA polymerase II transcription subunit 26 |
| NCBI Synonym Full Names: | mediator complex subunit 26 |
| NCBI Official Symbol: | MED26 |
| NCBI Official Synonym Symbols: | CRSP7; CRSP70 |
| NCBI Protein Information: | mediator of RNA polymerase II transcription subunit 26 |
| UniProt Protein Name: | Mediator of RNA polymerase II transcription subunit 26 |
| UniProt Synonym Protein Names: | Activator-recruited cofactor 70 kDa component; ARC70; Cofactor required for Sp1 transcriptional activation subunit 7; CRSP complex subunit 7; Mediator complex subunit 26; Transcriptional coactivator CRSP70 |
| Protein Family: | Mediator of RNA polymerase II transcription |
| UniProt Gene Name: | MED26 |
| UniProt Entry Name: | MED26_HUMAN |
| Antibodies | ELISA Kits |
| MED26 Antibody (PACO03180) | MED26 Colorimetric Cell-Based ELISA |
| MED26 Antibody (PACO10443) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
Anti-MED26 Antibody (CAB20500)
OverviewProduct Name:MED26 Rabbit pAbProduct Code:CAB20500Size:50uL, 100uLSynonyms:CRSP7, CRSP70Applications:
