Name: MED26 Antibody (PACO03180)
SKU: PACO03180
Availability: OutOfStock

Antibody Name:	MED26 Antibody
Antibody SKU:	PACO03180
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB
Recommended Dilutions:	WB:1:500-1:2000
Species Reactivity:	Human, Mouse
Immunogen:	synthesized peptide derived from the N-terminal region of human CRSP70.

Form:	Liquid
Storage Buffer:	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Synonyms:

MED26; ARC70; CRSP7; Mediator of RNA polymerase II transcription subunit 26; Activator-recruited cofactor 70 kDa component; ARC70; Cofactor required for Sp1 transcriptional activation subunit 7; CRSP complex subunit 7; Mediator complex subu

UniProt Protein Function:	MED26: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 26 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: nucleoplasm; Srb-mediator complex Molecular Function:protein binding; transcription coactivator activity Biological Process: regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter
NCBI Summary:	The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]
UniProt Code:	O95402
NCBI GenInfo Identifier:	158931130
NCBI Gene ID:	9441
NCBI Accession:	O95402.2
UniProt Secondary Accession:	O95402,Q0VGB6, A1A4S3,
UniProt Related Accession:	O95402
Molecular Weight:	10,359 Da
NCBI Full Name:	Mediator of RNA polymerase II transcription subunit 26
NCBI Synonym Full Names:	mediator complex subunit 26
NCBI Official Symbol:	MED26
NCBI Official Synonym Symbols:	CRSP7; CRSP70
NCBI Protein Information:	mediator of RNA polymerase II transcription subunit 26
UniProt Protein Name:	Mediator of RNA polymerase II transcription subunit 26
UniProt Synonym Protein Names:	Activator-recruited cofactor 70 kDa component; ARC70; Cofactor required for Sp1 transcriptional activation subunit 7; CRSP complex subunit 7; Mediator complex subunit 26; Transcriptional coactivator CRSP70
Protein Family:	Mediator of RNA polymerase II transcription
UniProt Gene Name:	MED26
UniProt Entry Name:	MED26_HUMAN