Name: MECOM Antibody (PACO55906)
SKU: PACO55906
Availability: OutOfStock

Antibody Name:	MECOM Antibody (PACO55906)
Antibody SKU:	PACO55906
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:500-1:1000
Species Reactivity:	Human
Immunogen:	Recombinant Human Histone-lysine N-methyltransferase MECOM protein (534-632AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

IHC image of PACO55906 diluted at 1:500 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Background:	Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-β signaling. Involved in hematopoiesis.
Synonyms:	MDS1 and EVI1 complex locus protein (Ecotropic virus integration site 1 protein homolog) (EVI-1) (Myelodysplasia syndrome 1 protein) (Myelodysplasia syndrome-associated protein 1), MECOM, EVI1

UniProt Protein Function:	Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.
NCBI Summary:	The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
UniProt Code:	Q03112
NCBI GenInfo Identifier:	145559472
NCBI Gene ID:	2122
NCBI Accession:	Q03112.2
UniProt Secondary Accession:	Q03112,Q16122, Q5HYI1, Q6MZS6, Q8NEI5, A1L4F3, A8KA00 B7Z8W7, B7ZLQ3, B7ZLQ4, C9JAK0, D3DNP7,
UniProt Related Accession:	Q13465,Q03112
Molecular Weight:	117,232 Da
NCBI Full Name:	MDS1 and EVI1 complex locus protein EVI1
NCBI Synonym Full Names:	MDS1 and EVI1 complex locus
NCBI Official Symbol:	MECOM
NCBI Official Synonym Symbols:	EVI1; MDS1; PRDM3; RUSAT2; MDS1-EVI1; AML1-EVI-1
NCBI Protein Information:	MDS1 and EVI1 complex locus protein EVI1
UniProt Protein Name:	MDS1 and EVI1 complex locus protein EVI1
UniProt Synonym Protein Names:	Ecotropic virus integration site 1 protein homolog; EVI-1
Protein Family:	MDS1 and EVI1 complex locus protein
UniProt Gene Name:	MECOM
UniProt Entry Name:	EVI1_HUMAN