Name: MECOM Antibody (PACO02896)
SKU: PACO02896
Availability: OutOfStock

Antibody Name:	MECOM Antibody
Antibody SKU:	PACO02896
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:	Human
Immunogen:	synthesized peptide derived from the N-terminal region of human PRDM3.

Form:	Liquid
Storage Buffer:	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Synonyms:

MECOM; MDS1; MDS1 and EVI1 complex locus protein MDS1; Myelodysplasia syndrome 1 protein; Myelodysplasia syndrome-associated protein 1

UniProt Protein Function:	MDS1: A chromosomal aberration involving MDS1 is found in a form of acute myeloid leukemia (AML). Translocation t(3;21) with AML1. 6 isoforms of the human protein are produced by alternative promoter.
UniProt Protein Details:	Protein type:Transcription factor Chromosomal Location of Human Ortholog: 3q26.2 Cellular Component: cytoplasm; cytosol; Golgi apparatus; histone deacetylase complex; intracellular membrane-bound organelle; nuclear speck; nucleoplasm; nucleus Molecular Function:DNA binding; histone-lysine N-methyltransferase activity; protein binding; transcription factor activity Biological Process: negative regulation of JNK cascade; negative regulation of programmed cell death; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; regulation of cell cycle
NCBI Summary:	The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
UniProt Code:	Q13465
NCBI GenInfo Identifier:	24211973
NCBI Gene ID:	2122
NCBI Accession:	Q13465.1
UniProt Related Accession:	Q13465,Q03112
Molecular Weight:
NCBI Full Name:	MDS1 and EVI1 complex locus protein MDS1
NCBI Synonym Full Names:	MDS1 and EVI1 complex locus
NCBI Official Symbol:	MECOM
NCBI Official Synonym Symbols:	EVI1; MDS1; PRDM3; RUSAT2; MDS1-EVI1; AML1-EVI-1
NCBI Protein Information:	MDS1 and EVI1 complex locus protein EVI1
UniProt Protein Name:	MDS1 and EVI1 complex locus protein MDS1
UniProt Synonym Protein Names:	Myelodysplasia syndrome 1 protein; Myelodysplasia syndrome-associated protein 1
Protein Family:	MDS1 and EVI1 complex locus protein
UniProt Gene Name:	MECOM