MDM2 Monoclonal Antibody (CAB23388)
- SKU:
- CAB23388
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | MDM2 Monoclonal Antibody |
| Product Code: | CAB23388 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC60296 |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | U2OS |
| Cellular Location: | Cytoplasm, Nucleus, nucleolus, nucleoplasm |
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
| Immunogen: | Recombinant protein of human MDM2. |
| Sequence: | CVIRE ICCER SSSSE STGTP SNPDL DAGVS EHSGD WLDQD SVSDQ FSVEF EVESL DSEDY SLSEE GQELS DEDDE VYQVT VYQAG ESDTD SFEED PEISL A |
| Synonyms: | HDMX, LSKB, hdm2, ACTFS |
| Calculated MW: | 11kDa/14kDa/24kDa/30kDa/33kDa/35kDa/48kDa/49kDa/55kDa |
| Observed MW: | 90kDa |
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