Description
Product Name: | MDM2 Monoclonal Antibody |
Product Code: | CAB23387 |
Reactivity: | Human |
Applications: | Immunohistochemistry |
Host Species: | Rabbit |
Purification Method: | Affinity purification |
Isotype: | IgG |
Clone No: | ARC60294 |
Reactivity: | Human |
Tested Applications: | IHC-P, ELISA |
Key Applications: | Immunohistochemistry |
Recommended Dilution: | IHC-P 1:50-1:200 |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
Cellular Location: | Cytoplasm, Nucleus, nucleolus, nucleoplasm |
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Immunogen: | Recombinant protein of human MDM2. |
Sequence: | CVIRE ICCER SSSSE STGTP SNPDL DAGVS EHSGD WLDQD SVSDQ FSVEF EVESL DSEDY SLSEE GQELS DEDDE VYQVT VYQAG ESDTD SFEED PEISL A |
Synonyms: | HDMX, LSKB, hdm2, ACTFS |
Calculated MW: | 55kDa |
Observed MW: | Refer to figures |