MCM9 Antibody (PACO41734)
- SKU:
- PACO41734
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MCM9 Antibody (PACO41734) |
| Antibody SKU: | PACO41734 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human DNA helicase MCM9 protein (1-391AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: MCM9 antibody at 0.8µg/ml. Lane 1: Mouse brain tissue. Lane 2: 293T whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 128, 73, 44, 85 kDa. Observed band size: 128 kDa. |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO41734 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO41734 at dilution of 1:100. |
| Background: | Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. |
| Synonyms: | DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9), MCM9, C6orf61 MCMDC1 |
| UniProt Protein Function: | MCM9: Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8- MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. Belongs to the MCM family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.6.4.12Chromosomal Location of Human Ortholog: 6q22.31Cellular Component: nucleusMolecular Function: ATP binding; DNA binding; helicase activityBiological Process: DNA replication; double-strand break repair via homologous recombination; female gamete generation; response to DNA damage stimulusDisease: Ovarian Dysgenesis 4 |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. [provided by RefSeq, Nov 2010] |
| UniProt Code: | Q9NXL9 |
| NCBI GenInfo Identifier: | 312284070 |
| NCBI Gene ID: | 254394 |
| NCBI Accession: | NP_060166.2 |
| UniProt Secondary Accession: | Q9NXL9,Q2KHJ0, Q8N5S5, Q9HCV5, B4DR30, B9DI77 |
| UniProt Related Accession: | Q9NXL9 |
| Molecular Weight: | 84,442 Da |
| NCBI Full Name: | DNA helicase MCM9 isoform 1 |
| NCBI Synonym Full Names: | minichromosome maintenance 9 homologous recombination repair factor |
| NCBI Official Symbol: | MCM9 |
| NCBI Official Synonym Symbols: | ODG4; MCMDC1; C6orf61; dJ329L24.1; dJ329L24.3 |
| NCBI Protein Information: | DNA helicase MCM9 |
| UniProt Protein Name: | DNA helicase MCM9 |
| UniProt Synonym Protein Names: | Mini-chromosome maintenance deficient domain-containing protein 1; Minichromosome maintenance 9 |
| Protein Family: | DNA helicase |
| UniProt Gene Name: | MCM9 |
| UniProt Entry Name: | MCM9_HUMAN |
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