MCIDAS Antibody (PACO46466)
- SKU:
- PACO46466
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MCIDAS Antibody (PACO46466) |
| Antibody SKU: | PACO46466 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Multicilin protein (3-110AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human prostate cancer using PACO46466 at dilution of 1:100. |
| Background: | Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway. Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1. |
| Synonyms: | Multicilin (Multiciliate differentiation and DNA synthesis-associated cell cycle protein) (McIdas protein) (Protein Idas), MCIDAS, IDAS MCI MCIN |
| UniProt Protein Function: | MCIDAS: Transcription regulator required for multiciliate cell differentiation. Acts by promoting transcription of genes required for multiciliate cell formation. Probably acts in a multiprotein complex. Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Belongs to the geminin family. Homodimer. Interacts with GMNN; targets GMNN to the nucleus, prevents GMNN interaction with CDT1 and competes with IDAS homodimerizationChromosomal Location of Human Ortholog: 5q11.2Cellular Component: nucleolus; nucleusMolecular Function: identical protein binding; protein bindingBiological Process: cilium biogenesis; positive regulation of transcription from RNA polymerase II promoter; regulation of mitotic cell cycle |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | D6RGH6 |
| NCBI GenInfo Identifier: | 342164929 |
| NCBI Gene ID: | 345643 |
| NCBI Accession: | D6RGH6.1 |
| UniProt Secondary Accession: | D6RGH6,C9JGY3, D6R920, F8KGQ8 |
| UniProt Related Accession: | D6RGH6 |
| Molecular Weight: | 41,720 Da |
| NCBI Full Name: | Multicilin |
| NCBI Synonym Full Names: | multiciliate differentiation and DNA synthesis associated cell cycle protein |
| NCBI Official Symbol: | MCIDAS |
| NCBI Official Synonym Symbols: | MCI; IDAS; MCIN |
| NCBI Protein Information: | multicilin |
| UniProt Protein Name: | Multicilin |
| UniProt Synonym Protein Names: | Multiciliate differentiation and DNA synthesis-associated cell cycle protein; Protein Idas |
| Protein Family: | Multicilin |
| UniProt Gene Name: | MCIDAS |
| UniProt Entry Name: | MCIN_HUMAN |
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