MBNL3 Antibody (PACO16657)
- SKU:
- PACO16657
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MBNL3 Antibody (PACO16657) |
| Antibody SKU: | PACO16657 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human MBNL3 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16657(MBNL3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16657(MBNL3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | This gene encodes a member of the muscleblind-like family of proteins. The encoded protein may function in regulation of alternative splicing and may play a role in the pathophysiology of myotonic dystrophy. Alternatively spliced transcript variants have been described. |
| Synonyms: | muscleblind-like splicing regulator 3 |
| UniProt Protein Function: | MBNL3: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction. Belongs to the muscleblind family. 5 isoforms of the human protein are produced by alternative splicing.Protein type: RNA-bindingChromosomal Location of Human Ortholog: Xq26.2Molecular Function: protein bindingBiological Process: regulation of RNA splicing |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the muscleblind-like family of proteins. The encoded protein may function in regulation of alternative splicing and may play a role in the pathophysiology of myotonic dystrophy. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009] |
| UniProt Code: | Q9NUK0 |
| NCBI GenInfo Identifier: | 26396510 |
| NCBI Gene ID: | 55796 |
| NCBI Accession: | Q9NUK0.2 |
| UniProt Secondary Accession: | Q9NUK0,Q5JXN8, Q5JXN9, Q5JXP4, Q6UDQ1, Q8IUR4, Q8TAD9 Q8TAF4, Q9H0Z7, Q9UF37 |
| UniProt Related Accession: | Q9NUK0 |
| Molecular Weight: | 27,687 Da |
| NCBI Full Name: | Muscleblind-like protein 3 |
| NCBI Synonym Full Names: | muscleblind like splicing regulator 3 |
| NCBI Official Symbol: | MBNL3 |
| NCBI Official Synonym Symbols: | CHCR; MBLX; MBXL; MBLX39 |
| NCBI Protein Information: | muscleblind-like protein 3 |
| UniProt Protein Name: | Muscleblind-like protein 3 |
| UniProt Synonym Protein Names: | Cys3His CCG1-required protein; Muscleblind-like X-linked protein; Protein HCHCR |
| Protein Family: | Muscleblind-like protein |
| UniProt Gene Name: | MBNL3 |
| UniProt Entry Name: | MBNL3_HUMAN |
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