Description
Antibody Name: | MBD4 Antibody (PACO10407) |
Antibody SKU: | PACO10407 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse |
Immunogen: | Human MBD4 |
Form: | Liquid |
Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | methyl-CpG binding domain protein 4;MBD4;MED1 ; |
UniProt Protein Function: | MBD4: Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. 3 isoforms of the human protein are produced by alternative splicing.Protein type: DNA repair, damage; EC 3.2.2.-; Apoptosis; DeoxyribonucleaseChromosomal Location of Human Ortholog: 3q21.3Cellular Component: nucleoplasm; cytoplasm; nucleus; chromatinMolecular Function: protein binding; satellite DNA binding; pyrimidine-specific mismatch base pair DNA N-glycosylase activity; endodeoxyribonuclease activityBiological Process: response to radiation; base-excision repair, AP site formation; DNA damage response, signal transduction resulting in induction of apoptosis; depyrimidination; base-excision repair; mitotic cell cycle G2/M transition DNA damage checkpoint; DNA repair; DNA catabolic process, endonucleolytic |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains an MBD domain at the N-terminus that functions both in binding to methylated DNA and in protein interactions and a C-terminal mismatch-specific glycosylase domain that is involved in DNA repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013] |
UniProt Code: | O95243 |
NCBI GenInfo Identifier: | 50400819 |
NCBI Gene ID: | 8930 |
NCBI Accession: | O95243.1 |
UniProt Secondary Accession: | O95243,Q2MD36, Q7Z4T3, Q96F09, B4DZN2, D3DNC3, D3DNC4 E9PEE4 |
UniProt Related Accession: | O95243 |
Molecular Weight: | 580 |
NCBI Full Name: | Methyl-CpG-binding domain protein 4 |
NCBI Synonym Full Names: | methyl-CpG binding domain protein 4 |
NCBI Official Symbol: | MBD4 |
NCBI Official Synonym Symbols: | MED1 |
NCBI Protein Information: | methyl-CpG-binding domain protein 4; G/T mismatch glycosylase; G/U mismatch glycosylase; methyl-CpG-binding protein MBD4; 3,N(4)-ethenocytosine glycosylase; methyl-CpG-binding endonuclease 1; mismatch-specific DNA N-glycosylase; putative methyl-CpG bindin |
UniProt Protein Name: | Methyl-CpG-binding domain protein 4 |
UniProt Synonym Protein Names: | Methyl-CpG-binding endonuclease 1; Methyl-CpG-binding protein MBD4; Mismatch-specific DNA N-glycosylase |
Protein Family: | Methyl-CpG-binding domain protein |
UniProt Gene Name: | MBD4 |
UniProt Entry Name: | MBD4_HUMAN |