MBD1 Polyclonal Antibody
- SKU:
- CAB2227
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | MBD1 Polyclonal Antibody |
| Product Code: | CAB2227 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Cellular Location: | Chromosome, Nucleus, Nucleus matrix, Nucleus speckle |
The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 386-655 of human MBD1 (NP_001191065.1). |
| Sequence: | LPSVW SESED GAGSP PPYRR RKRPS SARRH HLGPT LKPTL ATRTA QPDHT QAPTK QEAGG GFVLP PPGTD LVFLR EGASS PVQVP GPVAA STEAL LQEAQ CSGLS WVVAL PQVKQ EKADT QDEWT PGTAV LTSPV LVPGC PSKAV DPGLP SVKQE PPDPE EDKEE NKDDS ASKLA PEEEA GGAGT PVITE IFSLG GTRFR DTAVW LPSLQ GRHSG REDGC KVWET EDTVE PTSTS WNPRG WPGTH VSLSP PPASM MWVSC RRSWC PSSQS |
| Synonyms: | RFT, PCM1, CXXC3 |
| Calculated MW: | 67kDa |
| Observed MW: | Refer to figures |
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