MARS2 Antibody (PACO54150)
- SKU:
- PACO54150
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MARS2 Antibody (PACO54150) |
| Antibody SKU: | PACO54150 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Methionine--tRNA ligase, mitochondrial protein (225-460AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: K562 whole cell lysate. All lanes: MARS2 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 67 kDa. Observed band size: 67 kDa. |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO54150 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human prostate tissue using PACO54150 at dilution of 1:100. |
| Background: | ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). |
| Synonyms: | Methionine--tRNA ligase, mitochondrial (EC 6.1.1.10) (Methionyl-tRNA synthetase 2) (Mitochondrial methionyl-tRNA synthetase) (MtMetRS), MARS2 |
| UniProt Protein Function: | MARS2: Belongs to the class-I aminoacyl-tRNA synthetase family.Protein type: Other Amino Acids Metabolism - selenoamino acid; EC 6.1.1.10; Mitochondrial; LigaseChromosomal Location of Human Ortholog: 2q33.1Cellular Component: cytosol; mitochondrial matrixMolecular Function: methionine-tRNA ligase activityBiological Process: methionyl-tRNA aminoacylation; tRNA aminoacylation for protein translationDisease: Combined Oxidative Phosphorylation Deficiency 25; Spastic Ataxia 3, Autosomal Recessive |
| UniProt Protein Details: | |
| NCBI Summary: | This gene produces a mitochondrial methionyl-tRNA synthetase protein that is encoded by the nuclear genome and imported to the mitochondrion. This protein likely functions as a monomer and is predicted to localize to the mitochondrial matrix. Mutations in this gene are associated with the autosomal recessive neurodegenerative disease spastic ataxia-3 (SPAX3). [provided by RefSeq, Apr 2014] |
| UniProt Code: | Q96GW9 |
| NCBI GenInfo Identifier: | 85541638 |
| NCBI Gene ID: | 92935 |
| NCBI Accession: | Q96GW9.2 |
| UniProt Secondary Accession: | Q96GW9,Q76E79, Q8IW62, Q8N7N4, A0AVC3 |
| UniProt Related Accession: | Q96GW9 |
| Molecular Weight: | 66,591 Da |
| NCBI Full Name: | Methionine--tRNA ligase, mitochondrial |
| NCBI Synonym Full Names: | methionyl-tRNA synthetase 2, mitochondrial |
| NCBI Official Symbol: | MARS2 |
| NCBI Official Synonym Symbols: | MetRS; COXPD25; mtMetRS |
| NCBI Protein Information: | methionine--tRNA ligase, mitochondrial |
| UniProt Protein Name: | Methionine--tRNA ligase, mitochondrial |
| UniProt Synonym Protein Names: | Methionyl-tRNA synthetase 2; Mitochondrial methionyl-tRNA synthetase; MtMetRS |
| Protein Family: | |
| UniProt Gene Name: | MARS2 |
| UniProt Entry Name: | SYMM_HUMAN |
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