MARCH5 Antibody (PACO13515)
- SKU:
- PACO13515
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MARCH5 Antibody (PACO13515) |
| Antibody SKU: | PACO13515 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human MARCH5 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | membrane-associated ring finger (C3HC4) 5;MARCH5;FLJ20445;MARCH-V;MITOL;RNF153 ; |
| UniProt Protein Function: | MARCH5: Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.Protein type: Membrane protein, multi-pass; Ubiquitin conjugating system; Ligase; EC 6.3.2.19; Membrane protein, integral; EC 6.3.2.-; Ubiquitin ligaseChromosomal Location of Human Ortholog: 10q23.32-q23.33Cellular Component: endoplasmic reticulum membrane; mitochondrial outer membrane; membrane; endoplasmic reticulum; integral to membraneMolecular Function: GTPase binding; protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activityBiological Process: protein autoubiquitination; protein polyubiquitination |
| UniProt Protein Details: | |
| NCBI Summary: | MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9NX47 |
| NCBI GenInfo Identifier: | 15930072 |
| NCBI Gene ID: | 54708 |
| NCBI Accession: | AAH15480.1 |
| UniProt Secondary Accession: | Q9NX47 |
| UniProt Related Accession: | Q9NX47 |
| Molecular Weight: | |
| NCBI Full Name: | Membrane-associated ring finger (C3HC4) 5 |
| NCBI Synonym Full Names: | membrane-associated ring finger (C3HC4) 5 |
| NCBI Official Symbol: | MARCH5 |
| NCBI Official Synonym Symbols: | MITOL; RNF153; MARCH-V |
| NCBI Protein Information: | E3 ubiquitin-protein ligase MARCH5; ring finger protein 153; mitochondrial ubiquitin ligase; membrane-associated RING-CH protein V; membrane-associated RING finger protein 5 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase MARCH5 |
| UniProt Synonym Protein Names: | Membrane-associated RING finger protein 5; Membrane-associated RING-CH protein V; MARCH-V; Mitochondrial ubiquitin ligase; MITOL; RING finger protein 153 |
| Protein Family: | |
| UniProt Gene Name: | MARCH5 |
| UniProt Entry Name: | MARH5_HUMAN |
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