MARCH4 Antibody (PACO22319)
- SKU:
- PACO22319
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MARCH4 Antibody (PACO22319) |
| Antibody SKU: | PACO22319 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:50-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from internal of human MARCH4. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. |
| Synonyms: | E3 ubiquitin-protein ligase MARCH4 ; EC 6.3.2.-; Membrane-associated RING finger protein 4; Membrane-associated RING-CH protein IV; MARCH-IV |
| UniProt Protein Function: | MARCH4: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.Protein type: EC 6.3.2.19; EC 6.3.2.-; Membrane protein, multi-pass; Membrane protein, integral; Ubiquitin ligase; Ligase; Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 2q35Cellular Component: Golgi stack; trans-Golgi networkMolecular Function: ubiquitin-protein ligase activity |
| UniProt Protein Details: | |
| NCBI Summary: | MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010] |
| UniProt Code: | Q9P2E8 |
| NCBI GenInfo Identifier: | 59798475 |
| NCBI Gene ID: | 57574 |
| NCBI Accession: | Q9P2E8.2 |
| UniProt Secondary Accession: | Q9P2E8,Q4KMN7, Q86WR8 |
| UniProt Related Accession: | Q9P2E8 |
| Molecular Weight: | 45,528 Da |
| NCBI Full Name: | E3 ubiquitin-protein ligase MARCH4 |
| NCBI Synonym Full Names: | membrane associated ring-CH-type finger 4 |
| NCBI Official Symbol: | MARCH4 |
| NCBI Official Synonym Symbols: | RNF174; MARCH-IV |
| NCBI Protein Information: | E3 ubiquitin-protein ligase MARCH4 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase MARCH4 |
| UniProt Synonym Protein Names: | Membrane-associated RING finger protein 4; Membrane-associated RING-CH protein IV; MARCH-IV; RING finger protein 174 |
| Protein Family: | |
| UniProt Gene Name: | MARCH4 |
| UniProt Entry Name: | MARH4_HUMAN |
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