MARC1 Antibody (PACO19229)
- SKU:
- PACO19229
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MARC1 Antibody (PACO19229) |
| Antibody SKU: | PACO19229 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human MARC1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19229(MARC1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human normal liver tissue, Primary antibody: PACO19229(MARC1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19229(MARC1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | MOSC1 (MOCO sulphurase C-terminal domain containing 1), also known as MARC1, is a 337 amino acid, mitochondrial protein that is thought to function as an oxidoreductase. Existing as three alternatively spliced isoforms, MOSC1 contains one MOSC domain and binds molybdenum as a cofactor. The gene encoding MOSC1 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinsons disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma. |
| Synonyms: | mitochondrial amidoxime reducing component 1 |
| UniProt Protein Function: | MOSC1: As a component of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 1.-.-.-; Oxidoreductase; MitochondrialChromosomal Location of Human Ortholog: 1q41Cellular Component: mitochondrionMolecular Function: molybdenum ion binding; molybdopterin cofactor binding; nitrate reductase activityBiological Process: nitrate metabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q5VT66 |
| NCBI GenInfo Identifier: | 74746896 |
| NCBI Gene ID: | 64757 |
| NCBI Accession: | Q5VT66.1 |
| UniProt Secondary Accession: | Q5VT66,Q5VVS9, Q5VVT0, Q5VVT1, Q8N9P5, Q96FN8, Q9H6C7 A8K447, B2D078 |
| UniProt Related Accession: | Q5VT66 |
| Molecular Weight: | 28,439 Da |
| NCBI Full Name: | Mitochondrial amidoxime-reducing component 1 |
| NCBI Synonym Full Names: | mitochondrial amidoxime reducing component 1 |
| NCBI Official Symbol: | MARC1 |
| NCBI Official Synonym Symbols: | MOSC1 |
| NCBI Protein Information: | mitochondrial amidoxime-reducing component 1 |
| UniProt Protein Name: | Mitochondrial amidoxime-reducing component 1 |
| UniProt Synonym Protein Names: | Molybdenum cofactor sulfurase C-terminal domain-containing protein 1; MOSC domain-containing protein 1; Moco sulfurase C-terminal domain-containing protein 1 |
| Protein Family: | |
| UniProt Gene Name: | MARC1 |
| UniProt Entry Name: | MARC1_HUMAN |
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