Antibody Name:	Mapt Antibody (PACO28174)
Antibody SKU:	PACO28174
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA
Recommended Dilutions:
Species Reactivity:	Rat
Immunogen:	Recombinant Rat Microtubule-associated protein tau protein (2-752AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Background:

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Synonyms:

Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau), Mapt, Mtapt Tau

UniProt Protein Function:	Tau: a microtubule-associated protein that regulates microtubule assembly and stability. Apparently involved in the establishment and maintenance of neuronal polarity. Mutations can result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. Nine differentially spliced isoforms have been described. The short isoforms allow plasticity of the cytoskeleton, whereas the longer isoforms may preferentially play a role in its stabilization.
UniProt Protein Details:	Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 10q32.1 Cellular Component: axolemma; axon; axoneme; cell soma; cytoplasm; cytosol; dendrite; growth cone; internal side of plasma membrane; membrane; microtubule; microtubule associated complex; microtubule cytoskeleton; neuron projection; nuclear speck; nucleus; plasma membrane; postsynaptic density; tubulin complex Molecular Function:apolipoprotein binding; DNA binding; enzyme binding; Hsp90 protein binding; identical protein binding; microtubule binding; protein binding; protein complex binding; protein domain specific binding; protein homodimerization activity; protein kinase binding; protein phosphatase 2A binding; receptor agonist activity; SH3 domain binding Biological Process: adult walking behavior; apoptosis; axon cargo transport; axon extension; axonogenesis; brain development; female pregnancy; induction of apoptosis by oxidative stress; intracellular distribution of mitochondria; memory; microtubule cytoskeleton organization and biogenesis; mitochondrion transport along microtubule; negative regulation of intracellular transport; negative regulation of kinase activity; neurite development; neuron migration; positive regulation of axon extension; positive regulation of microtubule polymerization; positive regulation of superoxide release; regulation of autophagy; regulation of calcium-mediated signaling; regulation of microtubule polymerization or depolymerization; response to nutrient; response to organic substance; synapse organization and biogenesis
NCBI Summary:	a microtubule-associated protein; expression is found specifically in neurons [RGD, Feb 2006]
UniProt Code:	P19332
NCBI GenInfo Identifier:	13432197
NCBI Gene ID:	29477
NCBI Accession:	P19332.3
UniProt Secondary Accession:	P19332,Q63567, Q63677, Q9QW06,
UniProt Related Accession:	P19332
Molecular Weight:	80.4kD
NCBI Full Name:	Microtubule-associated protein tau
NCBI Synonym Full Names:	microtubule-associated protein tau
NCBI Official Symbol:	Mapt
NCBI Official Synonym Symbols:	Tau; pTau; Mtapt; RNPTAU
NCBI Protein Information:	microtubule-associated protein tau
UniProt Protein Name:	Microtubule-associated protein tau
UniProt Synonym Protein Names:	Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau
Protein Family:	Microtubule-associated protein
UniProt Gene Name:	Mapt