MAPKAPK5 Polyclonal Antibody
- SKU:
- CAB10705
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | MAPKAPK5 Polyclonal Antibody |
| Product Code: | CAB10705 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Cellular Location: | Cytoplasm, Nucleus |
The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 302-471 of human MAPKAPK5 (NP_003659.2). |
| Sequence: | PWLNS TEALD NVLPS AQLMM DKAVV AGIQQ AHAEQ LANMR IQDLK VSLKP LHSVN NPILR KRKLL GTKPK DSVYI HDHEN GAEDS NVALE KLRDV IAQCI LPQAG ENEDE KLNEV MQEAW KYNRE CKLLR DTLQS FSWNG RGFTD KVDRL KLAEI VKQVI EEQTT SHESQ |
| Synonyms: | MK5, MK-5, NCFD, PRAK, MAPKAP-K5 |
| Calculated MW: | 54kDa |
| Observed MW: | Refer to figures |
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