MAPKAPK3 Polyclonal Antibody
- SKU:
- CAB21655
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | MAPKAPK3 Polyclonal Antibody |
| Product Code: | CAB21655 |
| Reactivity: | Human, Mouse |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:2000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Cellular Location: | Cytoplasm, Nucleus |
This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human MAPKAPK3 (NP_004626.1). |
| Sequence: | MDGET AEEQG GPVPP PVAPG GPGLG GAPGG RREPK KYAVT DDYQL SKQVL GLGVN GKVLE CFHRR TGQKC ALKLL YDSPK ARQEV DHHWQ ASGGP HIVCI LDVYE NMHHG KRCLL IIMEC MEGGE LFSRI QERGD QAFTE REAAE IMRDI GTAIQ FLHSH NIAHR DVKPE NLLYT SKEKD AVLKL TDFGF AKETT QNALQ TPCYT PYYVA PEVLG PEKYD KSCDM WSLGV IMYIL LCGFP |
| Synonyms: | 3PK, MK3, MK-3, MDPT3, MAPKAP3, MAPKAP-K3, MAPKAPK-3 |
| Calculated MW: | 43kDa |
| Observed MW: | Refer to figures |
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