MAPK8IP2 Antibody (PACO45641)
- SKU:
- PACO45641
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | MAPK8IP2 Antibody (PACO45641) |
| Antibody SKU: | PACO45641 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human C-Jun-amino-terminal kinase-interacting protein 2 protein (470-570AA) |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: MAPK8IP2 antibody at 2.85µg/ml. Lane 1: U251 whole cell lysate. Lane 2: A549 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 88, 85, 65, 50 kDa. Observed band size: 88 kDa.. |
| Background: | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). |
| Synonyms: | C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2), MAPK8IP2, IB2 JIP2 PRKM8IPL |
| UniProt Protein Function: | MAPK8IP2: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Belongs to the JIP scaffold family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protein kinase, regulatory subunit; Activator Chromosomal Location of Human Ortholog: 22q13.33 Cellular Component: protein complex; cell soma; cytoplasm Molecular Function:MAP-kinase scaffold activity; protein binding; kinesin binding; beta-amyloid binding; protein complex binding; structural molecule activity; protein kinase binding; protein kinase activator activity Biological Process: nonassociative learning; regulation of synaptic transmission, glutamatergic; behavioral fear response; dendrite morphogenesis; MAPKKK cascade; mating behavior; signal complex assembly; social behavior; regulation of JNK cascade; positive regulation of stress-activated MAPK cascade; positive regulation of protein kinase activity; JNK cascade; regulation of receptor activity; regulation of excitatory postsynaptic membrane potential |
| NCBI Summary: | The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13387 |
| NCBI GenInfo Identifier: | 6912492 |
| NCBI Gene ID: | 23542 |
| NCBI Accession: | NP_036456.1 |
| UniProt Secondary Accession: | Q13387,Q96G62, Q99771, Q9NZ59, Q9UKQ4, |
| UniProt Related Accession: | Q13387 |
| Molecular Weight: | 87,975 Da |
| NCBI Full Name: | C-Jun-amino-terminal kinase-interacting protein 2 isoform 1 |
| NCBI Synonym Full Names: | mitogen-activated protein kinase 8 interacting protein 2 |
| NCBI Official Symbol: | MAPK8IP2 |
| NCBI Official Synonym Symbols: | IB2; JIP2; PRKM8IPL |
| NCBI Protein Information: | C-Jun-amino-terminal kinase-interacting protein 2; IB-2; islet-brain 2; JNK-interacting protein 2; homologous to mouse JIP-1; JNK MAP kinase scaffold protein 2; JNK MAP kinase scaffold protein JIP2 |
| UniProt Protein Name: | C-Jun-amino-terminal kinase-interacting protein 2 |
| UniProt Synonym Protein Names: | Islet-brain-2; IB-2; JNK MAP kinase scaffold protein 2; Mitogen-activated protein kinase 8-interacting protein 2 |
| UniProt Gene Name: | MAPK8IP2 |
| UniProt Entry Name: | JIP2_HUMAN |
| Antibodies | ELISA Kits |
| MAPK8IP2 Antibody (PACO03714) | JIP2 Colorimetric Cell-Based ELISA |
| MAPK8IP2 Antibody (PACO10382) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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